SERVER FOR THE IDENTIFICATION OF FUNCTIONAL REGIONS IN PROTEINS
ConSurf evolutionary conservation grades are derived from analysis of multiple sequence alignments. However, conserved sites are much more easily revealed when a 3-dimensional structure is colored by conservation. Thus, it is advisable to provide a structure. Predicted structures are also acceptable, for example from AlphaFold.
Insert PDB/UniProt ID
or upload a structure
Select chain identifier
Insert a sequence
Or, upload sequence File
If you want to predict the 3D structure using MODELLER, insert MODELLER key
ConSurf offer a 3D model predicted by HHPred and MODELLER for protein-query sequence. To use MODELLER a user is required a MODELLER-key. To obtain a MODELLER-key please contact the Sali lab. The key is freely available for academic users, and is provided automatically, without manual intervention, for users who are identifiable as such.
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