Please note: new default parameters
Homolog search algorithm
Number of iterations
- a curated protein sequence database which strives to provide a high level of annotation
Clean UniProt - a modified version of the UniProt database aimed to screen the more reliable sequences.UniRef90
- database cluster sequences and sub-fragments with 11 or more residues that have at least 90% sequence identity with each other (from any organism) into a single UniRef entry, displaying the sequence of a representativeUniProt
is the universal protein resource, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR.
Maximum homologs to collect
Maximal %ID between sequences
Minimal %ID for homologs
Let me select the sequences for the analysis manually out of BLAST results
The calculation method for the rate of evolution at each site in the MSA.
The Bayesian method was shown to significantly improve the accuracy of conservation scores estimations over the Maximum Likelihood method, in particular when a small number of sequences are used for the calculations. An additional advantage of the Bayesian method is that a confidence interval is assigned to each of the inferred evolutionary conservation score.
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