Amino Acid Conservation Scores ======================================= The layers for assigning grades are as follows. from -1.494 to -1.162 the grade is 9 from -1.162 to -0.830 the grade is 8 from -0.830 to -0.498 the grade is 7 from -0.498 to -0.166 the grade is 6 from -0.166 to 0.318 the grade is 5 from 0.318 to 0.954 the grade is 4 from 0.954 to 1.591 the grade is 3 from 1.591 to 2.227 the grade is 2 from 2.227 to 2.863 the grade is 1 If the difference between the colors of the CONFIDENCE INTERVAL COLORS is more than 3 or the msa number (under the column titled MSA) is less than 6, there is insufficient data and an * appears in the COLOR column. - POS: The position of the acid in the sequence. - SEQ: The acid one letter. - ATOM: When there's a model, The ATOM derived sequence in three letter code, including the acid's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores, next to it are the colors of the lower and upper bounds of the confidence interval - B/E: Burried (b) or Exposed (e) residue. - F/S: functional (f) or structural (s) residue (f - highly conserved and exposed, s - highly conserved and burried). - MSA DATA: The number of aligned sequences having an acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ ATOM SCORE COLOR CONFIDENCE INTERVAL B/E F/S MSA DATA RESIDUE VARIETY 1 E GLU:8:A -0.985 8 -1.223, -0.862 9,8 e f 20/150 E 85%, D 10%, Q 5% 2 Q GLN:9:A -0.796 7 -0.979, -0.730 8,7 e 86/150 Q 52%, R 24%, K 6%, S 4%, H 3%, L 2%, Y 1%, M 1%, P 1%, E 1%, N 1% 3 A ALA:10:A -1.166 9 -1.265, -1.132 9,8 e f 149/150 A 85%, S 10%, V 2%, K <1%, T <1%, Q <1% 4 C CYS:11:A -1.494 9 -1.538, -1.489 9,9 e f 149/150 C 5 D ASP:12:A -0.375 6 -0.578, -0.297 7,6 e 149/150 D 50%, E 10%, N 9%, V 8%, I 2%, K 2%, A 2%, T 2%, H 2%, Y 2%, Q 1%, R 1%, L 1%, G 1%, S 1%, M <1% 6 I ILE:13:A 0.764 4 0.261, 1.071 5,3 e 149/150 E 18%, S 13%, A 9%, V 9%, R 8%, L 5%, I 4%, Y 4%, M 4%, F 4%, P 4%, T 4%, N 3%, Q 3%, K 1%, C <1%, H <1% 7 C CYS:14:A -1.494 9 -1.538, -1.489 9,9 b s 149/150 C 8 R ARG:15:A -1.296 9 -1.383, -1.265 9,9 e f 149/150 R 89%, K 8%, H 1%, N <1% 9 L LEU:16:A 0.153 5 -0.185, 0.261 6,5 e 149/150 R 29%, K 20%, S 11%, L 10%, A 6%, T 4%, Q 4%, I 3%, E 2%, N 2%, G 1%, D 1%, V <1%, M <1%, H <1% 10 K LYS:17:A -1.209 9 -1.306, -1.179 9,9 e f 149/150 K 48%, R 48%, Q 2%, S <1%, T <1% 11 K LYS:18:A -1.424 9 -1.489, -1.383 9,9 e f 149/150 K 95%, R 4% 12 L LEU:19:A -0.335 6 -0.578, -0.185 7,6 e 149/150 L 27%, I 23%, V 18%, S 8%, T 5%, A 4%, Q 3%, G 2%, N 2%, M 1%, F 1%, H 1%, Y <1% 13 K LYS:20:A -0.935 8 -1.084, -0.862 8,8 e f 150/150 K 77%, R 20%, A 1%, G <1% 14 C CYS:21:A -1.494 9 -1.538, -1.489 9,9 b s 150/150 C 15 S SER:22:A -0.946 8 -1.084, -0.862 8,8 e f 150/150 D 57%, S 30%, T 5%, N 5%, E 1%, P <1% 16 K LYS:23:A -0.676 7 -0.862, -0.578 8,7 e 150/150 G 49%, R 22%, K 20%, A 4%, S 1%, E 1%, Q 1%, N <1% 17 E GLU:24:A 0.949 4 0.468, 1.071 4,3 e 150/150 E 27%, K 12%, D 9%, T 8%, Q 8%, V 6%, L 5%, I 4%, A 4%, G 3%, S 3%, R 3%, H 1%, P 1%, N 1%, M <1%, Y <1% 18 K LYS:25:A 0.548 4 0.261, 0.725 5,4 e 150/150 K 29%, R 19%, L 13%, Q 10%, I 4%, Y 4%, T 3%, V 2%, M 2%, E 2%, S 2%, F 1%, H 1%, A 1%, G 1%, P <1%, D <1% 19 P PRO:26:A -1.318 9 -1.420, -1.265 9,9 e f 150/150 P 96%, N 1%, V 1%, T <1%, K <1% 20 K LYS:27:A 1.423 3 0.725, 1.608 4,2 e 140/150 S 25%, V 14%, K 12%, R 10%, A 9%, T 7%, Q 5%, I 5%, E 2%, H 2%, N 1%, L 1%, C 1%, M <1% 21 C CYS:28:A -1.494 9 -1.538, -1.489 9,9 b s 150/150 C 22 A ALA:29:A 0.488 4 0.090, 0.725 5,4 e 150/150 S 27%, A 20%, T 16%, G 11%, Q 4%, D 4%, N 3%, V 2%, L 2%, E 2%, I 1%, H 1%, F 1%, M <1%, Y <1%, K <1%, R <1% 23 K LYS:30:A -0.030 5 -0.297, 0.090 6,5 e 150/150 N 19%, R 12%, H 12%, Q 11%, K 10%, S 10%, F 6%, A 3%, L 3%, T 3%, P 2%, Y 2%, V <1%, G <1%, W <1%, I <1% 24 C CYS:31:A -1.494 9 -1.538, -1.489 9,9 b s 150/150 C 25 L LEU:32:A 2.863 1 1.608, 3.021 2,1 e 150/150 L 18%, A 15%, V 12%, I 11%, R 10%, T 8%, Q 6%, S 4%, K 4%, E 3%, H 1%, F <1%, M <1%, Y <1%, G <1%, D <1% 26 K LYS:33:A 0.255 5 -0.055, 0.468 5,4 e 150/150 K 34%, R 16%, A 8%, Q 8%, N 7%, E 4%, S 4%, V 4%, T 4%, L 2%, I 1%, H <1%, W <1%, M <1%, G <1%, D <1% 27 N ASN:34:A 0.588 4 0.261, 0.725 5,4 e 150/150 N 16%, Y 15%, L 10%, S 10%, V 10%, H 8%, A 7%, I 4%, Q 4%, M 3%, T 3%, R 2%, F 2%, E 1% 28 N ASN:35:A 0.131 5 -0.185, 0.261 6,5 e 150/150 N 31%, G 31%, K 13%, R 6%, D 5%, S 5%, H 2%, Q 2%, E 1%, A <1%, Y <1% 29 W TRP:36:A 1.216 3 0.725, 1.608 4,2 e 150/150 R 16%, L 9%, T 8%, V 7%, W 6%, K 6%, F 6%, Y 6%, I 5%, A 4%, Q 4%, S 4%, G 4%, H 4%, E 3%, N 1%, M <1%, D <1% 30 E GLU:37:A 0.518 4 0.090, 0.725 5,4 e 150/150 E 38%, P 7%, Q 7%, D 6%, T 6%, H 6%, S 5%, R 4%, N 4%, A 4%, K 3%, L 2%, C 1%, I 1%, V <1% 31 C CYS:38:A -1.494 9 -1.538, -1.489 9,9 b s 150/150 C 32 R ARG:39:A 0.653 4 0.261, 0.725 5,4 e 150/150 T 20%, V 18%, R 8%, I 7%, S 7%, H 6%, Q 6%, E 6%, L 6%, K 2%, A 2%, N 2%, W 2%, F 1%, C <1%, M <1%, D <1% 33 Y TYR:40:A -1.040 8 -1.179, -0.979 9,8 e f 150/150 Y 78%, W 6%, F 6%, T 4%, A 1%, G 1%, V <1%, R <1%, S <1%, H <1% 34 S SER:41:A -0.359 6 -0.578, -0.297 7,6 e 150/150 S 36%, P 12%, T 9%, L 7%, E 7%, D 7%, G 5%, V 4%, A 2%, N 2%, K 2%, Y 1%, F <1%, I <1%, R <1% 35 P PRO:42:A 0.390 4 0.090, 0.468 5,4 e 138/150 P 28%, E 21%, D 13%, Q 13%, G 4%, T 4%, A 3%, K 2%, S 2%, F 1%, L 1%, V 1%, R <1%, N <1%, Y <1%, I <1% 36 K LYS:43:A 0.154 5 -0.185, 0.261 6,5 e 149/150 K 26%, R 16%, S 14%, V 9%, P 8%, T 7%, Q 4%, A 3%, L 2%, G 2%, I 2%, E 1%, D <1%, F <1%, H <1% 37 T THR:44:A 0.931 4 0.468, 1.071 4,3 e 147/150 T 11%, R 10%, L 9%, E 8%, K 8%, S 7%, V 6%, Q 6%, I 6%, A 4%, P 4%, G 4%, N 3%, H 3%, M 2%, D <1%, F <1%, Y <1% 38 K LYS:45:A -0.132 5 -0.400, -0.055 6,5 e 150/150 K 36%, R 18%, T 8%, A 6%, S 6%, I 5%, V 5%, Q 4%, N 4%, L 1%, E 1%, D 1%, F <1%, G <1% 39 R ARG:46:A -0.949 8 -1.084, -0.862 8,8 e f 150/150 R 52%, K 38%, E 2%, P 2%, S 1%, L <1%, A <1%, N <1%, W <1%, T <1%, Q <1% 40 S SER:47:A -0.403 6 -0.578, -0.297 7,6 e 131/150 R 35%, S 22%, T 14%, P 9%, K 3%, A 2%, G 2%, Q 2%, V 1%, E 1%, N 1%, L <1%, I <1%, H <1% 41 P PRO:48:A -0.189 6 -0.493, -0.055 6,5 e 143/150 G 36%, P 33%, A 7%, T 6%, N 6%, V 2%, E 2%, Q 1%, K 1%, R 1%, S <1%, D <1% 42 L LEU:49:A -0.077 5 -0.400, 0.090 6,5 e 148/150 L 35%, P 29%, F 8%, I 6%, V 4%, R 2%, H 2%, K 2%, A 2%, S 1%, E 1%, T 1%, Y 1%, G <1% 43 T THR:50:A -0.762 7 -0.922, -0.657 8,7 e 148/150 T 33%, P 24%, R 14%, K 10%, S 4%, A 4%, L 3%, V 1%, E 1%, N 1%, Q 1%, H <1% 44 R ARG:51:A -1.000 8 -1.132, -0.922 8,8 e f 148/150 R 51%, K 25%, A 8%, Q 4%, P 4%, S 2%, V 1%, T 1%, E <1%, H <1% 45 A ALA:52:A -0.154 5 -0.400, -0.055 6,5 e 148/150 G 37%, A 15%, R 12%, K 9%, S 6%, Q 6%, D 2%, E 2%, V 2%, H 2%, T 1%, L <1%, I <1%, N <1% 46 H HIS:53:A -0.207 6 -0.493, -0.055 6,5 e 150/150 Y 52%, H 18%, N 8%, R 6%, L 3%, S 2%, A 1%, K 1%, T 1%, Q 1%, E 1%, I <1%, D <1%, M <1%, F <1% 47 L LEU:54:A -0.574 7 -0.730, -0.493 7,6 b 150/150 L 34%, V 26%, I 24%, T 6%, M 2%, A 2%, Y 1%, F 1%, G <1%, E <1% 48 T THR:55:A -0.305 6 -0.493, -0.185 6,6 e 150/150 T 26%, E 26%, S 8%, R 8%, K 7%, N 4%, D 4%, Q 4%, A 1%, P 1%, H 1%, G 1%, F 1%, L <1%, M <1%, Y <1% 49 E GLU:56:A 0.462 4 0.090, 0.725 5,4 e 150/150 A 21%, E 18%, S 12%, Q 8%, K 6%, G 5%, D 4%, L 4%, T 3%, R 3%, M 3%, Y 2%, N 2%, I 1%, V 1%, F 1%, C <1% 50 V VAL:57:A -0.781 7 -0.922, -0.657 8,7 b 150/150 L 57%, V 26%, I 11%, A 2%, M <1%, Q <1%, F <1% 51 E GLU:58:A -1.101 8 -1.223, -1.032 9,8 e f 150/150 E 81%, Q 4%, R 4%, D 2%, T 2%, S 2%, K 1%, N 1%, H <1%, L <1% 52 S SER:59:A 0.925 4 0.468, 1.071 4,3 e 150/150 N 16%, S 14%, D 12%, A 12%, E 10%, K 9%, T 7%, Q 6%, R 4%, G 3%, H 2%, L 1%, V <1% 53 R ARG:60:A -1.053 8 -1.179, -0.979 9,8 e f 150/150 R 82%, E 7%, K 4%, Q 3%, S 1%, Y <1%, V <1%, A <1% 54 L LEU:61:A -0.618 7 -0.798, -0.493 7,6 b 150/150 L 70%, V 16%, I 7%, A 2%, M 1%, Q 1%, C <1%, E <1% 55 E GLU:62:A 0.889 4 0.468, 1.071 4,3 e 150/150 E 17%, A 16%, R 10%, Q 10%, D 8%, G 6%, K 6%, H 5%, T 4%, S 4%, V 2%, L 2%, I 2%, M <1%, N <1%, F <1% 56 R ARG:63:A 0.343 4 0.090, 0.468 5,4 e 149/150 R 26%, Q 24%, K 12%, E 7%, S 6%, A 5%, N 4%, I 2%, L 2%, D 2%, T 2%, V 2%, H 1% 57 L LEU:64:A -0.611 7 -0.798, -0.493 7,6 b 149/150 L 45%, M 15%, V 11%, T 8%, A 6%, I 4%, F 3%, H 2%, Y 1%, S <1%, C <1% 58 E GLU:65:A -1.237 9 -1.346, -1.179 9,9 e f 147/150 E 84%, Q 6%, K 4%, R 2%, A 1%, D <1%, W <1% 59 Q GLN:66:A 0.816 4 0.468, 1.071 4,3 e 146/150 Q 16%, A 15%, R 13%, E 12%, S 11%, K 7%, T 7%, N 4%, G 3%, H 2%, D 1%, I 1%, L 1%, F <1%, M <1%, V <1% 60 L LEU:67:A -0.182 6 -0.400, -0.055 6,5 b 134/150 L 64%, V 7%, M 5%, I 5%, A 5%, R 2%, Y 2%, Q 2%, F 2%, T <1%, E <1% 61 F PHE:68:A -0.461 6 -0.657, -0.297 7,6 b 122/150 L 68%, F 13%, V 6%, I 4%, M 1%, W 1%, C 1%, Y <1% 62 L LEU:69:A 1.651 2 1.071, 1.608 3,2 e 96/150 R 19%, S 11%, L 10%, K 10%, G 8%, A 7%, Q 7%, N 5%, H 4%, T 4%, E 4%, V 2%, Y 1%, I 1%, W 1%, F 1%, D 1% 63 L LEU:70:A 1.216 3 0.725, 1.608 4,2 e 86/150 Q 13%, E 12%, R 11%, K 10%, S 9%, T 8%, L 6%, A 4%, G 4%, N 4%, V 3%, Y 2%, D 2%, I 2%, P 1%, M 1% 64 I ILE:71:A 0.591 4 0.090, 0.725 5,4 b 85/150 L 49%, I 15%, V 11%, Q 4%, F 4%, R 3%, M 2%, Y 2%, T 2%, A 2%, H 1% 65 F PHE:72:A 1.243 3 0.725, 1.608 4,2 b 79/150 L 36%, F 15%, I 8%, M 5%, V 5%, H 3%, A 3%, Y 3%, E 3%, K 2%, D 2%, R 2%, P 2%, G 1%, N 1%, C 1% 66 P PRO:73:A -0.547 7 -0.798, -0.400 7,6 e 78/150 P 78%, S 6%, Q 3%, E 2%, G 2%, T 1%, A 1%, L 1%, D 1%, K 1% 67 R ARG:74:A 1.282 3 0.725, 1.608 4,2 e 77/150 D 19%, E 19%, N 12%, R 10%, G 9%, K 5%, S 5%, Q 5%, H 3%, L 2%, A 2%, V 1%, T 1%, I 1% 68 E GLU:75:A 2.830 1 1.608, 3.021 2,1 e 70/150 V 22%, L 12%, E 11%, D 10%, G 7%, R 4%, T 4%, A 4%, I 4%, Q 4%, H 2%, S 2%, M 2%, N 2%, W 1%, Y 1% 69 D ASP:76:A -0.290 6 -0.578, -0.185 7,6 e 67/150 D 56%, N 16%, E 10%, Q 7%, S 5%, A 1%, K 1% 70 L LEU:77:A 0.660 4 0.090, 1.071 5,3 b 59/150 L 37%, I 30%, V 8%, E 6%, M 3%, S 3%, T 1%, A 1%, R 1%, P 1%, F 1%, G 1% 71 D ASP:78:A 0.215 5 -0.185, 0.468 6,4 e 53/150 D 50%, E 18%, N 11%, L 7%, T 3%, S 3%, G 1%, K 1% 72 M MET:79:A 1.651 2 0.725, 1.608 4,2 e 48/150 E 16%, D 14%, A 10%, K 8%, Q 8%, S 6%, R 6%, M 4%, G 4%, T 4%, N 4%, P 4%, Y 4%, V 2%, H 2% 73 I ILE:80:A 0.646 4 0.090, 1.071 5,3 b 41/150 L 21%, A 17%, I 12%, M 12%, V 9%, T 7%, E 7%, D 2%, F 2%, K 2%, S 2%, C 2% 74 L LEU:81:A -0.202 6 -0.578, 0.090 7,5 b 37/150 L 64%, I 10%, V 5%, A 2%, M 2%, C 2%, R 2%, Y 2%, K 2%, T 2% 75 K LYS:82:A 1.723 2 0.725, 3.021 4,1 e 28/150 R 25%, K 17%, A 14%, Q 7%, S 7%, L 7%, N 3%, E 3%, G 3%, F 3%, I 3%, D 3% 76 M MET:83:A 0.749 4 -0.055, 1.071 5,3 e 21/150 S 33%, M 14%, D 9%, N 9%, Y 4%, K 4%, G 4%, Q 4%, T 4%, V 4%, R 4% 77 D ASP:84:A 2.116 2 0.725, 3.021 4,1 e 16/150 D 18%, V 12%, P 12%, T 12%, F 6%, A 6%, K 6%, S 6%, L 6%, M 6%, I 6% 78 S SER:85:A 0.249 5 -0.400, 0.725 6,4 e 11/150 D 45%, S 18%, N 18%, L 18% 79 L LEU:86:A 0.556 4 -0.493, 1.071 6,3 e 11/150 L 36%, S 36%, K 9%, Q 9%, D 9% 80 Q GLN:87:A 1.857 2 0.725, 3.021 4,1 e 9/150 Q 22%, P 22%, N 11%, L 11%, A 11%, I 11%, R 11% 81 D ASP:88:A 0.566 4 -0.297, 1.071 6,3 e 8/150 D 50%, R 12%, Q 12%, E 12%, M 12% 82 I ILE:89:A -0.431 6 -0.979, -0.055 8,5 b 6/150 I 66%, V 16%, S 16% 83 K LYS:90:A -0.106 5 -0.730, 0.261 7,5 e 6/150 K 50%, R 16%, A 16%, Q 16% 84 A ALA:91:A 0.198 5* -0.730, 0.725 7,4 e 4/150 A 50%, V 25%, E 25% 85 L LEU:92:A -0.126 5* -0.862, 0.261 8,5 b 4/150 L 50%, M 50% 86 L LEU:93:A -1.042 8* -1.420, -0.862 9,8 b 4/150 L 87 T THR:94:A -0.591 7* -1.306, -0.185 9,6 e 2/150 T 88 G GLY:95:A 0.431 4* -0.657, 1.071 7,3 e 2/150 G 50%, R 50% 89 L LEU:96:A 0.101 5* -0.862, 0.725 8,4 e 2/150 L 50%, H 50% *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.