Amino Acid Conservation Scores ======================================= The layers for assigning grades are as follows. from -1.430 to -1.112 the grade is 9 from -1.112 to -0.794 the grade is 8 from -0.794 to -0.477 the grade is 7 from -0.477 to -0.159 the grade is 6 from -0.159 to 0.309 the grade is 5 from 0.309 to 0.926 the grade is 4 from 0.926 to 1.544 the grade is 3 from 1.544 to 2.161 the grade is 2 from 2.161 to 2.779 the grade is 1 If the difference between the colors of the CONFIDENCE INTERVAL COLORS is more than 3 or the msa number (under the column titled MSA) is less than 6, there is insufficient data and an * appears in the COLOR column. - POS: The position of the acid in the sequence. - SEQ: The acid one letter. - ATOM: When there's a model, The ATOM derived sequence in three letter code, including the acid's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores, next to it are the colors of the lower and upper bounds of the confidence interval - B/E: Burried (b) or Exposed (e) residue. - F/S: functional (f) or structural (s) residue (f - highly conserved and exposed, s - highly conserved and burried). - MSA DATA: The number of aligned sequences having an acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ ATOM SCORE COLOR CONFIDENCE INTERVAL B/E F/S MSA DATA RESIDUE VARIETY 1 A ALA:23:A 0.949 3* 0.005, 1.517 5,3 e 5/150 A 40%, Y 20%, W 20%, E 20% 2 L LEU:24:A -0.305 6 -0.869, 0.005 8,5 e 8/150 L 75%, I 12%, S 12% 3 H HIS:25:A -0.483 7 -0.973, -0.220 8,6 e 7/150 H 71%, R 14%, Q 14% 4 W TRP:26:A 0.964 3 0.005, 1.517 5,3 e 9/150 G 44%, W 22%, L 11%, V 11%, R 11% 5 R ARG:27:A -0.767 7 -1.068, -0.558 8,7 e 14/150 R 78%, K 14%, G 7% 6 A ALA:28:A -0.556 7 -0.922, -0.316 8,6 e 17/150 A 41%, V 17%, G 17%, E 11%, L 5%, R 5% 7 A ALA:29:A -0.201 6 -0.628, 0.140 7,5 b 17/150 A 35%, F 23%, L 17%, S 5%, M 5%, I 5%, V 5% 8 G GLY:30:A 1.417 3 0.486, 2.782 4,1 b 22/150 G 50%, L 13%, A 13%, W 4%, V 4%, Y 4%, I 4%, T 4% 9 A ALA:31:A -0.237 6 -0.628, 0.005 7,5 b 28/150 A 32%, Y 28%, L 14%, S 7%, G 7%, W 3%, Q 3%, F 3% 10 A ALA:32:A 0.226 5 -0.113, 0.486 5,4 b 47/150 A 36%, V 17%, L 17%, S 10%, T 6%, G 4%, F 4%, C 2%, M 2% 11 T THR:33:A 1.326 3 0.722, 1.517 4,3 b 58/150 A 24%, L 17%, T 13%, V 13%, I 12%, G 10%, M 3%, P 1%, S 1%, F 1% 12 V VAL:34:A 1.402 3 0.722, 1.517 4,3 b 72/150 V 29%, F 13%, L 12%, G 12%, A 8%, T 8%, I 5%, M 4%, S 2%, C 1%, N 1% 13 L LEU:35:A 0.424 4 0.005, 0.722 5,4 b 83/150 L 22%, I 20%, A 15%, T 13%, F 8%, S 7%, V 4%, G 3%, M 3% 14 L LEU:36:A 0.231 5 -0.113, 0.486 5,4 b 98/150 L 25%, V 22%, A 15%, T 15%, S 5%, F 5%, I 5%, G 3%, M 3% 15 V VAL:37:A 1.536 3 0.722, 1.517 4,3 b 113/150 L 35%, V 24%, I 8%, A 7%, F 7%, G 3%, S 3%, M 2%, T 2%, C 1%, P <1% 16 I ILE:38:A 0.553 4 0.140, 0.722 5,4 b 123/150 L 34%, I 18%, V 14%, M 8%, T 6%, G 5%, F 5%, A 4%, C <1%, S <1% 17 V VAL:39:A 0.687 4 0.298, 1.035 5,3 b 127/150 L 40%, V 28%, I 6%, G 6%, A 5%, T 3%, F 3%, M 2%, S 1%, Y 1%, C <1% 18 L LEU:40:A 0.460 4 0.140, 0.722 5,4 b 129/150 L 31%, V 29%, I 16%, G 6%, M 3%, S 3%, A 3%, T 3%, F 1%, C <1%, Q <1% 19 L LEU:41:A 0.408 4 0.005, 0.486 5,4 b 132/150 L 31%, V 18%, F 18%, I 11%, Y 7%, M 6%, G 1%, T 1%, E <1%, S <1%, Q <1%, A <1% 20 A ALA:42:A 0.857 4 0.486, 1.035 4,3 b 133/150 L 27%, V 21%, I 17%, F 12%, A 6%, S 4%, T 3%, M 2%, C 2%, Y 1%, G <1% 21 G GLY:43:A 0.263 5 0.005, 0.486 5,4 b 134/150 G 25%, A 22%, S 17%, F 15%, I 5%, C 4%, L 4%, V 2%, T 1%, E <1%, N <1% 22 S SER:44:A -0.730 7 -0.869, -0.628 8,7 b 135/150 S 42%, A 37%, G 17%, T 2% 23 Y TYR:45:A 0.073 5 -0.220, 0.140 6,5 b 136/150 L 27%, S 19%, A 15%, T 9%, I 5%, V 5%, Y 4%, G 3%, F 2%, W 2%, C 2%, M <1% 24 L LEU:46:A 0.619 4 0.298, 0.722 5,4 b 137/150 A 37%, L 24%, G 11%, I 5%, V 5%, F 3%, S 2%, T 2%, Q 1%, C 1%, M 1%, P <1% 25 A ALA:47:A -0.074 5 -0.316, 0.005 6,5 b 137/150 V 28%, I 24%, M 19%, L 10%, A 7%, F 5%, E 2%, Y 2%, T <1% 26 V VAL:48:A -0.156 5 -0.403, 0.005 6,5 b 140/150 Y 51%, L 21%, F 8%, V 5%, H 5%, T 4%, I 1%, W 1%, Q <1%, C <1% 27 L LEU:49:A 2.294 1 1.035, 2.782 3,1 e 140/150 L 20%, D 14%, Y 9%, V 7%, F 7%, E 6%, I 6%, H 6%, Q 5%, A 4%, S 3%, T 2%, M 2%, P <1%, K <1%, R <1%, W <1%, C <1%, G <1% 28 A ALA:50:A 0.366 4 0.005, 0.486 5,4 b 140/150 A 35%, V 20%, L 12%, F 12%, I 10%, T 2%, M 2%, Q 2%, C 1%, S <1%, Y <1%, N <1% 29 E GLU:51:A -1.321 9 -1.405, -1.283 9,9 e f 139/150 E 96%, D 1%, S <1%, Q <1%, A <1% 30 R ARG:52:A 0.774 4 0.298, 1.035 5,3 e 138/150 R 42%, G 11%, H 10%, K 6%, A 4%, S 4%, N 3%, L 2%, E 2%, T 2%, Y 2%, D 1%, V 1%, P 1%, F <1%, Q <1%, M <1% 31 G GLY:53:A 2.779 1 1.517, 2.782 3,1 e 136/150 G 27%, D 17%, E 12%, A 7%, S 6%, N 5%, H 5%, R 5%, P 5%, Q 2%, Y 1%, T 1%, V <1%, K <1% 32 A ALA:54:A 0.980 3 0.486, 1.035 4,3 e 123/150 A 40%, V 14%, S 5%, I 5%, E 4%, N 4%, G 4%, T 4%, H 3%, Q 2%, R 2%, D 2%, L 1%, K 1%, M <1%, P <1% 33 P PRO:55:A -0.058 5 -0.316, 0.140 6,5 e 118/150 P 48%, Q 26%, E 5%, A 5%, K 2%, R 1%, T 1%, G 1%, V 1%, N 1%, H <1%, D <1%, L <1%, W <1% 34 G GLY:56:A 0.729 4 0.298, 1.035 5,3 e 137/150 G 30%, P 21%, D 14%, N 9%, E 9%, A 2%, R 2%, H 2%, K 2%, S 1%, V <1%, Q <1%, I <1%, T <1% 35 A ALA:57:A 0.163 5 -0.113, 0.298 5,5 e 141/150 A 26%, S 19%, E 12%, T 9%, G 8%, D 7%, N 6%, P 4%, H 3%, Q 1%, K <1% 36 Q GLN:58:A 0.957 3 0.486, 1.035 4,3 e 146/150 T 13%, N 13%, G 12%, K 10%, A 10%, S 8%, Q 6%, D 4%, P 4%, E 3%, V 2%, H 2%, R 2%, F 2%, M <1%, L <1%, I <1%, Y <1% 37 L LEU:59:A -0.729 7 -0.869, -0.628 8,7 b 148/150 F 41%, I 38%, L 6%, V 3%, M 3%, S 1%, N <1%, Y <1%, K <1%, G <1%, T <1%, E <1%, P <1%, A <1% 38 I ILE:60:A 1.728 2 1.035, 1.517 3,3 e 148/150 T 20%, G 12%, K 10%, E 9%, R 8%, S 7%, N 4%, H 4%, Q 4%, A 4%, V 4%, D 3%, P 2%, I 2%, Y <1% 39 T THR:61:A -0.428 6 -0.628, -0.316 7,6 e 150/150 S 51%, T 25%, N 9%, D 6%, G 5%, E 1%, Q <1% 40 Y TYR:62:A -0.639 7 -0.813, -0.558 8,7 b 150/150 I 41%, F 26%, Y 14%, V 5%, L 4%, A 4%, R 2%, P <1%, G <1%, N <1% 41 P PRO:63:A 0.175 5 -0.113, 0.298 5,5 b 150/150 P 42%, G 32%, A 6%, S 4%, T 3%, E 2%, F 2%, I 1%, W 1%, M <1%, L <1%, K <1%, D <1%, V <1% 42 R ARG:64:A 0.358 4 0.005, 0.486 5,4 e 150/150 D 52%, A 7%, R 6%, E 6%, K 4%, L 3%, Q 3%, H 3%, N 3%, S 2%, T 2%, G 1%, Y 1%, I 1%, V <1% 43 A ALA:65:A -0.776 7 -0.922, -0.693 8,7 b 150/150 A 64%, S 18%, G 13%, T 3%, P <1% 44 L LEU:66:A -0.323 6 -0.558, -0.220 7,6 b 150/150 L 46%, I 16%, V 12%, F 9%, M 9%, W 2%, S <1%, G <1%, Y <1%, A <1% 45 W TRP:67:A -1.187 9 -1.323, -1.113 9,9 b s 150/150 W 84%, Y 14%, F <1% 46 W TRP:68:A -1.087 8 -1.242, -1.021 9,8 b 150/150 W 92%, F 4%, Y 2%, L 1% 47 S SER:69:A -0.600 7 -0.755, -0.484 7,7 b 150/150 A 55%, S 22%, T 11%, G 6%, V 2%, C 2% 48 V VAL:70:A 0.297 5 0.005, 0.486 5,4 b 150/150 I 32%, V 28%, L 10%, F 9%, A 8%, C 5%, M 2%, T 1%, Y <1%, W <1%, S <1%, G <1% 49 E GLU:71:A -0.542 7 -0.693, -0.484 7,7 b 150/150 V 53%, T 15%, A 9%, I 6%, E 4%, S 4%, M 4%, N <1%, G <1%, Q <1% 50 T THR:72:A -1.326 9 -1.405, -1.283 9,9 b s 150/150 T 92%, S 3%, I 1%, V 1%, M <1%, R <1% 51 A ALA:73:A -0.111 5 -0.316, 0.005 6,5 b 150/150 L 27%, M 26%, V 17%, I 16%, A 6%, F 3%, T 2%, S <1%, G <1% 52 T THR:74:A -1.107 8 -1.200, -1.068 9,8 b 150/150 T 84%, S 7%, A 5%, G <1%, C <1%, I <1%, L <1%, M <1% 53 T THR:75:A -1.430 9 -1.475, -1.405 9,9 b s 150/150 T 98%, S <1%, A <1% 54 V VAL:76:A -1.294 9 -1.364, -1.242 9,9 b s 150/150 V 90%, T 4%, I 3%, M 1%, G <1%, L <1% 55 G GLY:77:A -1.427 9 -1.475, -1.405 9,9 b s 150/150 G 56 Y TYR:78:A -1.299 9 -1.405, -1.242 9,9 e f 145/150 Y 95%, F 3%, S <1%, A <1% 57 G GLY:79:A -1.321 9 -1.405, -1.283 9,9 b s 150/150 G 96%, S 2%, N 1%, E <1% 58 D ASP:80:A -1.265 9 -1.364, -1.242 9,9 e f 150/150 D 94%, E 3%, G 1%, N <1% 59 L LEU:81:A 0.286 5 0.005, 0.486 5,4 e 150/150 V 24%, I 22%, L 10%, M 9%, Y 6%, R 6%, F 4%, T 4%, A 3%, K 3%, H 2%, E 1%, Q 1%, S <1% 60 Y TYR:82:A 0.564 4 0.140, 0.722 5,4 e 150/150 Y 30%, V 18%, T 14%, A 10%, F 9%, S 9%, I 4%, H 1%, N 1%, W <1% 61 P PRO:83:A -1.381 9 -1.475, -1.364 9,9 e f 150/150 P 99%, A <1% 62 V VAL:84:A 0.089 5 -0.220, 0.298 6,5 e 150/150 V 46%, I 16%, K 9%, T 8%, Q 5%, A 4%, E 2%, H 2%, L 1%, R 1%, Y <1%, S <1%, D <1% 63 T THR:85:A -1.337 9 -1.405, -1.323 9,9 e f 150/150 T 94%, S 4%, G 1% 64 L LEU:86:A 2.779 1 1.517, 2.782 3,1 e 150/150 P 20%, T 16%, A 14%, V 10%, L 9%, G 4%, F 4%, D 3%, I 3%, W 3%, N 2%, E 2%, S 1%, Q 1%, M 1%, Y <1%, H <1%, R <1% 65 W TRP:87:A 2.762 1 1.517, 2.782 3,1 e 150/150 L 23%, A 12%, E 12%, G 10%, T 10%, I 6%, W 5%, S 4%, V 4%, M 2%, P 2%, Q 2%, Y 1%, N <1%, R <1%, K <1%, F <1% 66 G GLY:88:A -1.397 9 -1.475, -1.364 9,9 b s 150/150 G 99%, A <1% 67 R ARG:89:A -0.793 7 -0.922, -0.693 8,7 e 150/150 R 65%, K 25%, Q 7%, M 1%, H <1% 68 C CYS:90:A 1.006 3 0.486, 1.035 4,3 b 150/150 L 24%, I 22%, F 17%, V 16%, M 7%, A 5%, T 2%, C 2%, W 1%, G <1%, S <1% 69 V VAL:91:A -0.012 5 -0.220, 0.140 6,5 b 150/150 V 36%, I 26%, L 21%, F 8%, A 4%, W 1%, C 1%, T <1% 70 A ALA:92:A -0.799 8 -0.922, -0.693 8,7 b 150/150 A 68%, G 19%, S 5%, T 4%, C 2%, F <1% 71 V VAL:93:A 0.347 4 0.005, 0.486 5,4 b 150/150 V 30%, A 16%, S 15%, G 11%, F 8%, L 6%, I 4%, T 4%, M 3%, C 1% 72 V VAL:94:A 2.230 1 1.035, 2.782 3,1 b 150/150 V 22%, L 19%, G 15%, I 12%, A 8%, F 8%, C 5%, M 5%, T 1%, P 1%, S <1% 73 V VAL:95:A -0.462 6 -0.628, -0.316 7,6 b 150/150 L 42%, V 22%, C 9%, I 8%, T 6%, A 4%, F 2%, Q 2%, M 1%, Y <1%, E <1%, W <1% 74 M MET:96:A -0.996 8 -1.113, -0.922 9,8 b 150/150 M 63%, A 16%, I 4%, L 4%, T 4%, S 3%, V 2%, F <1%, C <1% 75 V VAL:97:A 0.594 4 0.298, 0.722 5,4 b 150/150 L 28%, I 26%, V 24%, F 8%, M 6%, T 3%, A 3%, S 1% 76 A ALA:98:A 1.924 2 1.035, 2.782 3,1 b 150/150 A 18%, L 14%, G 13%, V 11%, F 10%, T 8%, C 7%, S 6%, M 4%, I 4%, Y 2% 77 G GLY:99:A -1.136 9 -1.242, -1.068 9,8 b s 150/150 G 92%, A 6%, D <1%, S <1% 78 I ILE:100:A -0.653 7 -0.813, -0.558 8,7 b 150/150 I 48%, V 19%, L 14%, Y 11%, F 4%, M 1%, G <1% 79 T THR:101:A -0.096 5 -0.316, 0.005 6,5 b 150/150 G 36%, A 32%, S 9%, L 9%, I 5%, T 3%, V 2%, M 1%, P <1%, C <1% 80 S SER:102:A -0.291 6 -0.484, -0.220 7,6 b 150/150 L 44%, I 18%, V 12%, T 7%, F 7%, M 6%, S 2%, A <1%, E <1% 81 F PHE:103:A -0.159 5 -0.403, 0.005 6,5 b 150/150 I 32%, L 23%, F 22%, V 12%, A 4%, Y 2%, N 1%, C <1%, S <1%, T <1% 82 G GLY:104:A -0.821 8 -0.973, -0.755 8,7 b 148/150 G 47%, A 40%, S 9%, T 1%, I <1%, V <1% 83 L LEU:105:A -0.307 6 -0.484, -0.220 7,6 b 148/150 V 29%, L 25%, M 12%, T 8%, A 5%, Y 5%, I 4%, S 4%, F 3%, Q <1%, G <1% 84 V VAL:106:A -0.365 6 -0.558, -0.220 7,6 b 145/150 P 37%, V 31%, L 9%, I 7%, A 5%, F 4%, W 2%, T 1%, M <1% 85 T THR:107:A -0.908 8 -1.021, -0.813 8,8 b 142/150 T 64%, V 10%, A 10%, I 7%, S 4%, L 1%, F <1% 86 A ALA:108:A -0.538 7 -0.693, -0.403 7,6 b 138/150 G 44%, A 36%, S 10%, P 4%, R 2%, M <1%, K <1%, E <1% 87 A ALA:109:A -0.385 6 -0.558, -0.316 7,6 b 133/150 I 30%, T 23%, S 14%, A 9%, V 7%, L 6%, N 2%, Y 2%, G <1%, F <1%, M <1%, C <1%, Q <1% 88 L LEU:110:A 0.062 5 -0.220, 0.140 6,5 b 129/150 L 38%, I 31%, V 16%, F 10%, M 1%, T 1%, A <1% 89 A ALA:111:A -0.776 7 -0.922, -0.693 8,7 b 119/150 A 67%, S 15%, T 9%, G 4%, V 3%, F <1% 90 T THR:112:A -0.687 7 -0.869, -0.628 8,7 b 111/150 S 45%, T 27%, A 22%, D 1%, N 1%, V <1%, Y <1% 91 W TRP:113:A 0.254 5 -0.113, 0.486 5,4 b 107/150 W 39%, A 17%, G 12%, Y 10%, F 6%, I 3%, L 2%, E 1%, T <1%, V <1%, N <1%, R <1%, K <1%, S <1% 92 F PHE:114:A -0.784 7 -0.973, -0.693 8,7 b 102/150 F 66%, L 16%, I 6%, V 5%, M 3% 93 V VAL:115:A -0.218 6 -0.484, -0.113 7,5 e 87/150 V 42%, I 26%, A 12%, L 9%, M 3%, F 2%, T 2%, Y 1% 94 G GLY:116:A 1.098 3 0.486, 1.517 4,3 e 65/150 E 33%, G 21%, Q 12%, A 9%, D 7%, S 7%, K 3%, N 1%, T 1%, F 1% 95 R ARG:117:A -0.432 6 -0.693, -0.220 7,6 e 42/150 R 73%, E 7%, Q 7%, G 4%, S 2%, K 2%, L 2% 96 E GLU:118:A 0.097 5 -0.403, 0.486 6,4 e 14/150 E 35%, D 28%, Q 21%, R 7%, K 7% 97 Q GLN:119:A -0.575 7* -1.113, -0.316 9,6 e 4/150 Q 75%, E 25% *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.