Amino Acid Conservation Scores ======================================= - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 E GLU8:A -0.838 8 -1.073,-0.686 8,7 24/150 D,Q,E 2 Q GLN9:A -0.894 8 -1.026,-0.813 8,7 99/150 H,L,E,R,K,S,Y,Q,M 3 A ALA10:A -1.307 9 -1.394,-1.282 9,9 146/150 S,Q,V,A,K 4 C CYS11:A -1.473 9 -1.522,-1.465 9,9 148/150 C 5 D ASP12:A -0.534 7 -0.686,-0.457 7,6 148/150 S,Q,V,A,L,E,H,I,R,T,N,D,K 6 I ILE13:A -0.055 5 -0.266, 0.125 6,5 148/150 A,M,Y,V,Q,S,G,F,P,K,T,N,R,I,E,L 7 C CYS14:A -1.473 9 -1.522,-1.465 9,9 148/150 C 8 R ARG15:A -1.275 9 -1.357,-1.244 9,9 148/150 Q,R,K,G 9 L LEU16:A 0.215 4 -0.024, 0.305 5,4 148/150 S,M,A,V,Q,E,L,H,N,K,T,R,I 10 K LYS17:A -1.163 9 -1.282,-1.118 9,8 148/150 K,Q,R 11 K LYS18:A -1.445 9 -1.502,-1.429 9,9 148/150 K,R 12 L LEU19:A -0.316 6 -0.540,-0.153 7,5 148/150 G,S,C,V,Q,A,M,L,F,I,T,N 13 K LYS20:A -1.088 8 -1.203,-1.026 9,8 149/150 R,K,A 14 C CYS21:A -1.474 9 -1.522,-1.465 9,9 150/150 C 15 S SER22:A -0.940 8 -1.073,-0.871 8,8 150/150 A,N,T,D,S,G 16 K LYS23:A -0.695 7 -0.871,-0.616 8,7 150/150 Q,A,G,S,R,K,N,E 17 E GLU24:A 0.561 3 0.125, 0.831 5,2 150/150 H,L,E,R,I,T,D,K,N,G,S,V,Q,A 18 K LYS25:A 0.402 4 0.125, 0.530 5,3 150/150 G,S,V,Q,Y,M,A,L,E,H,F,I,R,K,T 19 P PRO26:A -1.345 9 -1.429,-1.282 9,9 150/150 P,S,Q,M 20 K LYS27:A 0.997 2 0.530, 1.294 3,1 137/150 N,T,K,R,I,E,L,P,A,Q,V,S 21 C CYS28:A -1.474 9 -1.522,-1.465 9,9 150/150 C 22 A ALA29:A 0.438 4 0.125, 0.530 5,3 150/150 A,Q,V,S,G,D,T,N,K,R,I,E,L,H 23 K LYS30:A -0.117 5 -0.367,-0.024 6,5 150/150 N,T,K,I,R,L,A,Y,Q,V,S,G,W,F,H,P 24 C CYS31:A -1.474 9 -1.522,-1.465 9,9 150/150 C 25 L LEU32:A 2.454 1 1.294, 2.510 1,1 150/150 Q,V,A,M,S,F,R,I,N,T,D,K,L,E,H 26 K LYS33:A 0.195 4 -0.153, 0.305 5,4 150/150 H,L,E,I,R,T,D,K,N,G,S,V,Q,A 27 N ASN34:A 0.249 4 -0.024, 0.305 5,4 150/150 S,Q,V,Y,A,H,L,I,R,D,N,K,T,F,W 28 N ASN35:A 0.175 4 -0.153, 0.305 5,4 150/150 E,H,I,R,N,K,D,G,S,Q,A 29 W TRP36:A 0.487 4 0.125, 0.530 5,3 150/150 H,W,F,S,A,M,Q,V,Y,E,L,N,K,T,R,I 30 E GLU37:A 0.217 4 -0.024, 0.305 5,4 150/150 Q,A,G,S,C,I,R,T,K,D,N,P,L,E,H 31 C CYS38:A -1.474 9 -1.522,-1.465 9,9 150/150 C 32 R ARG39:A 0.974 2 0.530, 1.294 3,1 150/150 I,R,D,T,N,K,L,E,H,V,Q,M,A,G,S,C 33 Y TYR40:A -1.025 8 -1.162,-0.925 9,8 150/150 G,S,Y,H,L,I,T,W,F 34 S SER41:A -0.307 6 -0.540,-0.153 7,5 150/150 G,S,V,Q,Y,A,P,F,L,E,R,I,K,N,D,T 35 P PRO42:A 0.147 5 -0.153, 0.305 5,4 150/150 G,S,Q,V,A,L,P,E,H,R,I,N,T,K,D 36 K LYS43:A 0.266 4 -0.024, 0.530 5,3 150/150 A,M,Q,V,S,G,H,P,D,N,T,K,I,R,E,L 37 T THR44:A 0.683 3 0.305, 0.831 4,2 142/150 L,E,R,I,D,N,K,T,G,S,Q,V,A,M,P,H,F 38 K LYS45:A -0.690 7 -0.871,-0.616 8,7 137/150 I,R,K,N,T,D,P,E,Q,V,A,G,S 39 R ARG46:A -1.083 8 -1.203,-1.026 9,8 148/150 S,G,T,D,K,R,E,P,L,H 40 S SER47:A -0.793 7 -0.925,-0.686 8,7 144/150 D,T,K,R,E,P,A,Q,Y,V,S 41 P PRO48:A -0.357 6 -0.616,-0.266 7,6 149/150 E,P,H,F,N,K,T,R,I,S,G,A,Q 42 L LEU49:A -0.511 7 -0.752,-0.367 7,6 139/150 R,I,K,N,T,F,H,L,P,E,Y,V,A 43 T THR50:A -0.647 7 -0.813,-0.540 7,7 149/150 D,T,K,R,I,E,L,P,A,Q,S 44 R ARG51:A -0.700 7 -0.871,-0.616 8,7 149/150 G,S,V,Q,A,M,P,R,K,T 45 A ALA52:A -0.272 6 -0.457,-0.153 6,5 150/150 P,E,H,R,T,D,N,K,G,S,Q,V,A 46 H HIS53:A -0.688 7 -0.871,-0.616 8,7 143/150 R,D,K,N,L,E,H,Q,Y,A,S 47 L LEU54:A -0.639 7 -0.813,-0.540 7,7 149/150 I,T,D,F,H,L,Y,V,M,G,S 48 T THR55:A -0.519 7 -0.686,-0.457 7,6 149/150 V,Q,A,G,S,R,K,D,N,T,F,H,L,E 49 E GLU56:A 0.149 5 -0.153, 0.305 5,4 149/150 F,D,T,N,K,E,L,H,A,M,V,Q,Y,S,G 50 V VAL57:A -0.957 8 -1.073,-0.871 8,8 149/150 L,I,V,M,A 51 E GLU58:A -1.137 8 -1.244,-1.073 9,8 149/150 S,G,Q,Y,E,L,H,T,D,K,I,R 52 S SER59:A 0.529 3 0.125, 0.831 5,2 149/150 H,E,R,T,K,N,D,G,S,V,Q,M,A 53 R ARG60:A -0.961 8 -1.073,-0.871 8,8 149/150 A,Q,Y,S,K,D,I,R,E 54 L LEU61:A -0.757 7 -0.925,-0.686 8,7 150/150 R,I,V,M,K,N,L 55 E GLU62:A 1.165 1 0.530, 1.294 3,1 150/150 D,T,N,K,I,R,E,L,F,H,P,A,M,Y,Q,V,S,G 56 R ARG63:A 1.218 1 0.831, 1.294 2,1 150/150 E,L,D,T,N,K,I,R,H,F,C,S,M,A,Y,Q,V 57 L LEU64:A -0.485 6 -0.686,-0.367 7,6 149/150 L,I,T,D,F,V,M,A 58 E GLU65:A -1.230 9 -1.320,-1.203 9,9 145/150 Q,R,T,K,D,L,E,H 59 Q GLN66:A 1.463 1 0.831, 1.294 2,1 141/150 L,E,R,T,K,D,N,G,S,Y,V,Q,A,M,H,F 60 L LEU67:A -0.164 6 -0.457,-0.024 6,5 131/150 F,R,I,K,T,L,E,Q,V,M,A 61 F PHE68:A -0.363 6 -0.616,-0.266 7,6 126/150 L,T,N,I,W,F,M,Y,V 62 L LEU69:A 2.321 1 1.294, 2.510 1,1 103/150 Q,V,A,G,S,C,I,R,D,T,K,N,L,E,H 63 L LEU70:A 2.124 1 0.831, 2.510 2,1 89/150 G,S,Q,Y,V,A,M,H,F,L,E,I,R,D,N,K,T 64 I ILE71:A 0.724 3 0.305, 0.831 4,2 80/150 F,I,R,T,N,K,L,H,Q,V,M,A,S 65 F PHE72:A 1.451 1 0.530, 2.510 3,1 73/150 V,Q,Y,A,G,S,R,I,D,K,T,F,H,L 66 P PRO73:A -0.193 6 -0.540,-0.024 7,5 71/150 A,Q,S,G,T,N,I,R,H,E,P,L 67 R ARG74:A 0.973 2 0.305, 1.294 4,1 65/150 L,P,E,R,K,D,T,N,G,S,Q,V 68 E GLU75:A 2.185 1 1.294, 2.510 1,1 61/150 N,D,T,K,I,E,L,A,M,V,Q,Y,S,G,F,H,P 69 D ASP76:A -0.026 5 -0.367, 0.125 6,5 59/150 S,A,Q,H,E,P,N,D,T 70 L LEU77:A 1.653 1 0.831, 2.510 2,1 56/150 F,I,T,D,N,L,P,E,H,V,Q,A 71 D ASP78:A 0.295 4 -0.153, 0.530 5,3 52/150 L,E,R,N,D,K,G,S,A 72 M MET79:A 0.942 2 0.305, 1.294 4,1 46/150 A,M,Q,V,G,T,N,K,D,R,E,P,H 73 I ILE80:A 0.481 4 -0.024, 0.831 5,2 37/150 S,V,A,M,L,P,E,I,T,D 74 L LEU81:A 0.200 4 -0.266, 0.530 6,3 35/150 S,Q,V,Y,M,L,I,R,T 75 K LYS82:A 1.676 1 0.831, 2.510 2,1 31/150 S,A,Q,E,L,H,K,D,N,R 76 M MET83:A 1.327 1 0.530, 2.510 3,1 21/150 N,D,K,H,L,E,Q,A,M,C,S 77 D ASP84:A 1.369 1 0.305, 2.510 4,1 16/150 S,M,L,E,R,N,T,K,D,F 78 S SER85:A 0.850 2* 0.125, 1.294 5,1 15/150 I,T,D,H,L,E,Q,A,M,S 79 L LEU86:A -0.647 7 -0.977,-0.457 8,6 14/150 S,L,Q,Y,I 80 Q GLN87:A 0.913 2* 0.125, 1.294 5,1 13/150 H,L,E,R,N,K,D,T,S,Q 81 D ASP88:A 0.992 2* 0.125, 1.294 5,1 12/150 S,E,L,D,K,Q 82 I ILE89:A 1.072 2* -0.024, 2.510 5,1 8/150 I,M,D,A,P 83 K LYS90:A -0.244 6 -0.925, 0.125 8,5 6/150 K,I,S 84 A ALA91:A 1.000 2* -0.024, 2.510 5,1 6/150 K,D,A,V,I 85 L LEU92:A 0.738 3* -0.266, 1.294 6,1 5/150 L,A,V,Q 86 L LEU93:A -0.025 5* -0.813, 0.530 7,3 4/150 N,L 87 T THR94:A -0.221 6* -0.925, 0.305 8,4 3/150 T,I 88 G GLY95:A 0.800 3* -0.266, 1.294 6,1 3/150 G,T,Q 89 L LEU96:A -0.576 7* -1.244,-0.153 9,5 1/150 L *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.