Amino Acid Conservation Scores ======================================= - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 G GLY1:A -1.122 9 -1.201,-1.077 9,9 72/150 G 2 P PRO2:A -0.268 6 -0.457,-0.131 7,6 90/150 C,F,L,V,S,I,P,T,R 3 H HIS3:A -1.148 9 -1.191,-1.138 9,9 127/150 H,Y 4 S SER4:A -0.997 9 -1.077,-0.971 9,9 128/150 S,C,W,T,R 5 L LEU5:A 0.121 5 -0.131, 0.214 6,4 130/150 I,F,M,P,T,L,Y 6 R ARG6:A -0.087 5 -0.307, 0.085 6,5 130/150 K,H,S,L,M,Q,W,Y,D,T,R,I 7 Y TYR7:A -0.626 7 -0.800,-0.524 8,7 130/150 I,F,G,H,Y,L,N 8 F PHE8:A -0.206 6 -0.457,-0.028 7,5 130/150 H,Y,S,L,E,F,I 9 V VAL9:A 3.198 1 1.912, 3.379 1,1 130/150 D,Y,E,A,R,T,V,L,S,H,F,M,Q 10 T THR10:A -0.771 8 -0.890,-0.700 8,8 132/150 Y,I,A,T,L,V,S,M 11 A ALA11:A 0.715 2 0.363, 1.008 4,1 133/150 M,S,V,L,T,R,A,I,G 12 V VAL12:A -0.394 7 -0.586,-0.307 7,6 133/150 M,W,S,V,L,A,R,T,I 13 S SER13:A -0.846 8 -0.971,-0.800 9,8 133/150 S,Y,F,W,A,T 14 R ARG14:A -0.084 5 -0.307, 0.085 6,5 115/150 G,D,N,P,E,R,A,K,S,H,L,Q,W 15 P PRO15:A -0.625 7 -0.800,-0.524 8,7 134/150 N,G,E,P,A,R,S,H,Q 16 G GLY16:A 0.093 5 -0.131, 0.214 6,4 134/150 S,V,L,G,D,N,E,T,R,A,I 17 L LEU17:A 0.499 3 0.214, 0.744 4,2 131/150 G,P,E,R,I,K,H,S,V,L,Q,F 18 G GLY18:A 0.301 4 -0.028, 0.535 5,3 135/150 W,Q,H,S,K,V,L,T,A,R,E,G,N,D 19 E GLU19:A 0.132 4 -0.131, 0.363 6,4 134/150 Y,D,E,T,I,K,L,V,M,Q,F 20 P PRO20:A -0.615 7 -0.800,-0.524 8,7 135/150 P,A,T,H,S 21 R ARG21:A 0.386 3 0.085, 0.535 5,3 135/150 F,Q,W,V,L,K,S,H,E,A,R,N,G 22 Y TYR22:A 0.197 4 -0.131, 0.363 6,4 135/150 F,H,Y,L,V 23 M MET23:A 0.211 4 -0.028, 0.363 5,4 135/150 I,T,V,L,S,F,M,Q 24 E GLU24:A 2.056 1 1.364, 1.912 1,1 135/150 E,R,T,A,I,G,Y,D,N,M,F,H,S,V 25 V VAL25:A -0.572 7 -0.700,-0.457 8,7 135/150 L,V,S,M,G,I,P,A,T 26 G GLY26:A -0.632 7 -0.800,-0.524 8,7 136/150 A,E,C,G,V 27 Y TYR27:A -0.226 6 -0.457,-0.131 7,6 136/150 F,I,Q,M,L,Y,S 28 V VAL28:A -0.819 8 -0.931,-0.751 9,8 137/150 F,M,A,V,L 29 D ASP29:A -1.118 9 -1.191,-1.077 9,9 137/150 N,D 30 D ASP30:A -0.273 6 -0.457,-0.131 7,6 137/150 E,T,R,D,N,G,S,H 31 T THR31:A -0.362 6 -0.524,-0.224 7,6 139/150 F,Q,M,L,I,A,G,V,S,H,K,T,R,E,N,D 32 E GLU32:A 0.074 5 -0.224, 0.214 6,4 139/150 Q,V,L,H,I,R,A,P,E 33 F PHE33:A -0.049 5 -0.307, 0.085 6,5 138/150 L,V,F,M,G,I,A,X 34 V VAL34:A 1.042 1 0.535, 1.364 3,1 140/150 F,Q,M,L,I,A,Y,G,V,H,S,K,T,E,N,D 35 R ARG35:A 0.156 4 -0.131, 0.363 6,4 140/150 H,S,K,L,W,Q,C,F,Y,G,N,R,T 36 F PHE36:A -0.613 7 -0.800,-0.524 8,7 140/150 C,F,L,Y 37 D ASP37:A -0.639 7 -0.800,-0.586 8,7 140/150 S,H,Y,N,D 38 S SER38:A -1.052 9 -1.109,-1.008 9,9 140/150 N,H,S,C,R 39 D ASP39:A 0.218 4 -0.028, 0.363 5,4 140/150 K,H,L,V,Y,D,N,E,T,R,A,I 40 A ALA40:A -0.340 6 -0.586,-0.224 7,6 78/150 G,Y,D,E,P,A,S,V 41 E GLU41:A 1.551 1 1.008, 1.912 1,1 77/150 Q,L,V,S,K,R,A,E,P,D,G 42 N ASN42:A 0.229 4 -0.028, 0.363 5,4 139/150 N,D,G,I,A,R,T,P,E,L,V,S,K,C 43 P PRO43:A 0.653 2 0.363, 0.744 4,2 138/150 R,A,P,E,G,Q,M,K,L 44 R ARG44:A -0.224 6 -0.457,-0.131 7,6 140/150 Q,W,M,S,K,R,T,E,I,G,N 45 Y TYR45:A 2.443 1 1.364, 3.379 1,1 140/150 N,D,R,T,E,V,S,H,K,C,Y,G,I,A,L,F,Q,M 46 E GLU46:A 0.002 5 -0.224, 0.085 6,5 141/150 D,R,E,I,H,K,V,L,Q,M 47 P PRO47:A -0.658 8 -0.800,-0.586 8,7 141/150 S,H,L,P,E,R,A 48 R ARG48:A -0.128 6 -0.386,-0.028 7,5 141/150 L,K,S,C,M,Q,G,I,T,A,R 49 A ALA49:A -0.285 6 -0.457,-0.224 7,6 140/150 E,P,A,T,N,G,Q,V,S 50 R ARG50:A 0.125 5 -0.131, 0.214 6,4 141/150 V,L,S,K,Q,M,D,G,A,R,E,P 51 W TRP51:A -0.834 8 -1.008,-0.751 9,8 141/150 C,W,L,K 52 M MET52:A 0.484 3 0.214, 0.744 4,2 141/150 I,T,A,R,D,M,V,L,S 53 E GLU53:A 0.525 3 0.214, 0.744 4,2 141/150 R,A,E,P,N,D,G,Q,V,H,S,K 54 Q GLN54:A 0.426 3 0.085, 0.535 5,3 118/150 W,Q,K,H,V,E,P,A,R,I,G,Y,D,N 55 E GLU55:A 0.760 2 0.363, 1.008 4,1 117/150 A,T,E,I,N,D,Q,M,F,H,S,K,V,L 56 G GLY56:A 0.918 1 0.535, 1.008 3,1 138/150 K,S,H,V,P,E,T,R,A,G,D,N 57 P PRO57:A -0.186 6 -0.386,-0.028 7,5 142/150 Q,M,S,L,V,R,T,A,P,E,D 58 E GLU58:A 0.376 4 0.085, 0.535 5,3 141/150 K,H,Q,D,N,G,E,R,A 59 Y TYR59:A -0.466 7 -0.645,-0.386 8,7 142/150 L,D,V,H,Y,F 60 W TRP60:A -0.583 7 -0.800,-0.457 8,7 142/150 E,W,F,L 61 E GLU61:A 0.563 3 0.214, 0.744 4,2 142/150 G,D,N,E,A,T,R,K,S,H,L 62 R ARG62:A 2.074 1 1.364, 1.912 1,1 142/150 E,P,T,A,R,D,G,M,W,Q,L,V,K,S,H 63 E GLU63:A 1.774 1 1.008, 1.912 1,1 142/150 Q,M,V,L,S,I,E,N,D,Y,G 64 T THR64:A -0.955 9 -1.043,-0.890 9,8 142/150 E,T,R,K,S,L,N 65 Q GLN65:A 1.110 1 0.744, 1.364 2,1 142/150 E,P,A,R,T,I,G,N,Q,W,K,L 66 K LYS66:A 3.008 1 1.912, 3.379 1,1 142/150 G,D,N,E,T,A,R,I,K,S,V,L,M,F 67 A ALA67:A 2.213 1 1.364, 1.912 1,1 142/150 N,D,R,T,E,H,S,V,C,Y,G,A,I,L,W,Q,M,F 68 K LYS68:A 0.603 3 0.214, 0.744 4,2 142/150 F,Q,W,M,V,L,S,K,I,R,T,E,N 69 G GLY69:A 3.362 1 1.912, 3.379 1,1 141/150 A,X,I,Y,G,Q,M,F,T,R,E,N,D,H,S,K,V 70 N ASN70:A 2.845 1 1.364, 3.379 1,1 141/150 A,X,I,Y,G,Q,W,T,R,E,N,D,C,S,H,K,V 71 E GLU71:A -0.009 5 -0.224, 0.085 6,5 141/150 K,H,S,M,W,Q,G,D,E,X,A,T,I 72 Q GLN72:A 0.157 4 -0.131, 0.363 6,4 141/150 X,E,P,R,A,D,G,F,Q,L,K,H 73 S SER73:A 2.266 1 1.364, 3.379 1,1 141/150 K,S,H,V,C,N,E,R,T,L,M,W,Q,F,G,X,A,I 74 F PHE74:A 2.055 1 1.364, 1.912 1,1 141/150 V,H,S,C,N,D,T,E,L,F,Q,Y,G,I,A,X 75 R ARG75:A 0.260 4 -0.028, 0.363 5,4 141/150 D,N,E,R,T,K,S,H,V,G,Y,P,X,A,I,L,M,Q 76 V VAL76:A 1.576 1 1.008, 1.912 1,1 141/150 V,H,S,K,T,R,E,N,D,F,W,M,L,I,A,X,Y,G 77 D ASP77:A 0.987 1 0.535, 1.008 3,1 141/150 C,K,S,H,E,R,T,D,N,F,Q,L,I,X,A,G,Y 78 L LEU78:A -0.624 7 -0.800,-0.524 8,7 142/150 I,F,M,A,V,L 79 R ARG79:A 1.426 1 1.008, 1.912 1,1 142/150 Q,W,H,K,V,T,A,R,E,P,G,N,D 80 T THR80:A 0.839 2 0.535, 1.008 3,1 142/150 T,R,A,E,I,N,D,M,F,H,S,K,L,V 81 L LEU81:A 0.802 2 0.363, 1.008 4,1 141/150 I,A,T,G,W,M,L,V,S 82 L LEU82:A 0.249 4 -0.028, 0.363 5,4 141/150 L,V,S,H,K,F,Q,M,N,I,R,A,P 83 G GLY83:A 1.548 1 1.008, 1.912 1,1 141/150 P,A,I,G,Y,Q,F,E,T,R,D,N,K,H,S,V 84 Y TYR84:A -0.369 6 -0.586,-0.224 7,6 141/150 Q,W,V,L,S,H,I,R,N,Y 85 Y TYR85:A -0.741 8 -0.890,-0.645 8,8 141/150 Y,H,S,N,T,R,F 86 N ASN86:A -1.035 9 -1.109,-1.008 9,9 141/150 K,S,D,N,A,Q 87 Q GLN87:A -0.715 8 -0.846,-0.645 8,8 142/150 E,R,D,Q,W,L,K,H,S 88 S SER88:A -0.821 8 -0.931,-0.751 9,8 142/150 T,A,R,G,S 89 K LYS89:A 0.743 2 0.363, 1.008 4,1 143/150 W,Q,K,S,H,L,E,T,A,R,G,D,N 90 G GLY90:A 1.205 1 0.744, 1.364 2,1 88/150 G,D,N,P,A,T,S,H,V 91 G GLY91:A -0.598 7 -0.751,-0.524 8,7 146/150 S,V,G,D,R,A,X,E 92 S SER92:A -0.527 7 -0.700,-0.457 8,7 146/150 N,Y,I,X,P,T,A,L,V,S,F,M,W 93 H HIS93:A -1.154 9 -1.201,-1.138 9,9 147/150 H,Q,X 94 T THR94:A -0.704 8 -0.846,-0.645 8,8 147/150 T,X,M,I,S,N,V 95 I ILE95:A 3.372 1 1.912, 3.379 1,1 147/150 I,X,T,R,N,Y,F,W,L,V 96 Q GLN96:A -1.062 9 -1.138,-1.043 9,9 148/150 L,V,Q,M 97 V VAL97:A 3.379 1 1.912, 3.379 1,1 148/150 C,V,K,S,H,E,R,T,N,F,M,W,Q,L,I,G,Y 98 I ILE98:A -0.227 6 -0.457,-0.131 7,6 148/150 F,M,V,L,K,S,I,P,T,R,D 99 S SER99:A 2.286 1 1.364, 3.379 1,1 148/150 R,T,A,I,Y,N,M,W,F,C,H,S,V,L 100 G GLY100:A -0.938 9 -1.043,-0.890 9,8 148/150 A,R,N,G,S 101 C CYS101:A -1.155 9 -1.201,-1.138 9,9 148/150 C 102 E GLU102:A -0.122 5 -0.307,-0.028 6,5 148/150 E,I,Y,N,D,S,H,K,V 103 V VAL103:A 0.196 4 -0.131, 0.363 6,4 147/150 I,E,P,T,R,C,M,Q,W,V,L 104 G GLY104:A 0.623 3 0.214, 0.744 4,2 148/150 D,N,G,Y,E,A,T,R,L,H,S,C,Q,W 105 S SER105:A 0.019 5 -0.224, 0.214 6,4 148/150 Q,S,L,X,E,P,T,R,A,G,Y,D,N 106 D ASP106:A -0.560 7 -0.700,-0.457 8,7 148/150 D,N,K,G,H,E,A 107 G GLY107:A -0.093 5 -0.307, 0.085 6,5 150/150 A,R,G,N,D,Q,W,K,L 108 R ARG108:A 0.010 5 -0.224, 0.085 6,5 150/150 N,G,I,T,R,E,L,V,H,S,K,F,Q 109 L LEU109:A 0.705 2 0.214, 1.008 4,1 88/150 L,V,S,F,R 110 L LEU110:A -0.008 5 -0.224, 0.085 6,5 150/150 I,R,T,E,P,Y,G,F,Q,V,L,S,K 111 R ARG111:A 0.036 5 -0.224, 0.214 6,4 150/150 E,A,T,R,D,N,G,M,Q,L,K,H,S 112 G GLY112:A -0.720 8 -0.890,-0.645 8,8 150/150 R,A,W,V,G,S 113 Y TYR113:A 0.010 5 -0.224, 0.214 6,4 149/150 T,N,D,Y,F,Q,S,H 114 Q GLN114:A 3.379 1 1.912, 3.379 1,1 149/150 I,G,Y,F,M,W,Q,L,E,T,R,D,N,C,V,K,S,H 115 Q GLN115:A -0.517 7 -0.700,-0.457 8,7 149/150 Q,W,K,H,E,R,D,Y 116 Y TYR116:A 3.372 1 1.912, 3.379 1,1 149/150 S,H,K,V,C,N,D,R,E,L,Q,W,F,Y,A,X,I 117 A ALA117:A -0.591 7 -0.751,-0.524 8,7 150/150 A,Q,T,L,Y,S,G 118 Y TYR118:A -0.822 8 -0.971,-0.751 9,8 149/150 Y,G,X,F,I 119 D ASP119:A -0.919 9 -1.008,-0.846 9,8 150/150 E,N,D,Y 120 G GLY120:A -1.118 9 -1.191,-1.077 9,9 150/150 R,G 121 C CYS121:A 0.673 2 0.363, 0.744 4,2 149/150 C,W,Q,L,H,K,A,T,R,X,E,N,D,G 122 D ASP122:A -1.033 9 -1.109,-1.008 9,9 150/150 E,T,V,D 123 Y TYR123:A -0.451 7 -0.645,-0.307 8,6 150/150 F,P,W,L,Y,H 124 I ILE124:A -0.001 5 -0.224, 0.085 6,5 150/150 L,V,F,I,P,M 125 A ALA125:A -0.097 5 -0.307,-0.028 6,5 150/150 V,S,I,E,A,T,R,G,Y 126 L LEU126:A -0.218 6 -0.457,-0.028 7,5 150/150 I,P,Y,G,F,W,M,L 127 N ASN127:A -0.882 8 -0.971,-0.846 9,8 150/150 K,S,D,N,E,F 128 E GLU128:A 0.177 4 -0.131, 0.363 6,4 150/150 H,K,L,Q,M,D,R,T,A,E,P 129 D ASP129:A -0.158 6 -0.386,-0.028 7,5 150/150 E,P,A,T,R,G,D,N,Q,K,S,V 130 L LEU130:A -0.325 6 -0.524,-0.224 7,6 150/150 N,R,A,T,P,E,I,S,K,L,Q,M 131 K LYS131:A 0.895 2 0.535, 1.008 3,1 150/150 S,H,K,V,N,T,R,E,L,W,Q,M,Y,G,A,P 132 T THR132:A -0.556 7 -0.700,-0.457 8,7 150/150 F,Q,V,S,K,I,A,R,T,P,N,G 133 W TRP133:A -0.174 6 -0.457,-0.028 7,5 149/150 W,F,Y,L 134 T THR134:A -0.283 6 -0.457,-0.224 7,6 148/150 X,E,R,T,A,I,N,M,S,V,L 135 A ALA135:A -0.753 8 -0.890,-0.700 8,8 149/150 S,V,T,A,P 136 A ALA136:A -0.195 6 -0.386,-0.131 7,6 149/150 G,P,E,A,R,T,S,L,V,W,F 137 D ASP137:A -0.020 5 -0.224, 0.085 6,5 149/150 F,Q,M,V,H,S,K,I,T,A,R,E,N,D,G 138 M MET138:A 0.986 1 0.535, 1.364 3,1 149/150 F,Q,M,L,I,A,P,G,V,S,K,R,T,E,N,D 139 A ALA139:A -0.131 6 -0.307,-0.028 6,5 150/150 I,A,T,E,P,Y,G,Q,M,V,K 140 A ALA140:A -1.131 9 -1.191,-1.109 9,9 150/150 A,S,H 141 L LEU141:A -0.039 5 -0.224, 0.085 6,5 150/150 A,R,E,G,Q,W,H,V,L 142 I ILE142:A -0.149 6 -0.386,-0.028 7,5 150/150 I,E,P,A,R,D,N,Y,F,M,V,L,K,S 143 T THR143:A -0.620 7 -0.751,-0.524 8,7 150/150 T,M,I,S,G,L,D 144 K LYS144:A 0.101 5 -0.131, 0.214 6,4 150/150 K,L,V,W,Q,E,R,A,T 145 H HIS145:A -0.111 5 -0.307,-0.028 6,5 150/150 E,R,G,Y,N,Q,K,H,S,V,L 146 K LYS146:A 0.056 5 -0.224, 0.214 6,4 150/150 Q,W,M,F,S,K,V,R,T,E,I,N 147 W TRP147:A 0.562 3 0.085, 0.744 5,2 150/150 Y,R,E,L,V,W,M,F 148 E GLU148:A -0.474 7 -0.645,-0.386 8,7 150/150 E,R,Q,V,D,N,K 149 Q GLN149:A 0.531 3 0.214, 0.744 4,2 148/150 D,N,G,P,E,T,A,R,V,K,H,S,Q 150 A ALA150:A 0.883 2 0.535, 1.008 3,1 148/150 M,V,K,S,H,I,P,E,A,R,T,D,N,G 151 G GLY151:A 1.283 1 0.744, 1.364 2,1 149/150 I,E,P,R,A,D,N,G,Q,L,K,H,S 152 E GLU152:A 3.379 1 1.912, 3.379 1,1 146/150 T,R,E,N,D,V,S,K,I,A,X,Y,G,F,W,Q,M,L 153 A ALA153:A -0.065 5 -0.307, 0.085 6,5 148/150 I,A,T,R,E,P,N,G,F,M,L,V,S 154 E GLU154:A 0.013 5 -0.224, 0.214 6,4 150/150 K,H,L,W,Q,G,Y,D,N,E,T,R,A 155 R ARG155:A 3.082 1 1.912, 3.379 1,1 149/150 E,R,T,D,N,V,K,S,H,I,P,A,G,Y,F,M,Q,L 156 L LEU156:A 3.379 1 1.912, 3.379 1,1 150/150 I,A,Y,F,M,Q,W,L,E,R,T,D,N,V,K,S,H 157 R ARG157:A -0.488 7 -0.645,-0.386 8,7 150/150 E,R,T,N,G,Q,K,S 158 A ALA158:A 0.358 4 0.085, 0.535 5,3 150/150 L,Q,M,F,Y,G,A,I,S,H,V,N,D,T,R,E 159 Y TYR159:A -0.190 6 -0.457,-0.028 7,5 150/150 F,C,Q,W,L,V,H,S,K,I,E,Y 160 L LEU160:A -0.666 8 -0.846,-0.586 8,7 150/150 I,F,L,V,Y 161 E GLU161:A -0.321 6 -0.524,-0.224 7,6 150/150 E,A,T,G,D,N,Q,K 162 G GLY162:A 0.205 4 -0.028, 0.363 5,4 150/150 G,N,D,R,A,T,E,H,S,K,V,Q 163 T THR163:A 3.026 1 1.912, 3.379 1,1 150/150 K,S,L,V,Q,F,G,D,P,E,T,R,A,I 164 C CYS164:A -1.106 9 -1.191,-1.077 9,9 150/150 C,W 165 V VAL165:A 0.151 4 -0.131, 0.363 6,4 150/150 F,M,V,L,K,I,P,T,R,A 166 E GLU166:A 0.601 3 0.214, 0.744 4,2 150/150 V,K,H,S,D,E,T,R,L,M,Q,W,G,Y,P,A 167 W TRP167:A 2.380 1 1.364, 3.379 1,1 148/150 G,Y,P,A,I,L,M,W,Q,F,N,E,R,T,S,C 168 L LEU168:A -0.809 8 -0.931,-0.751 9,8 148/150 L,V,I 169 R ARG169:A 0.905 1 0.535, 1.008 3,1 146/150 L,K,H,S,C,Q,N,G,E,P,X,R 170 R ARG170:A -0.123 5 -0.307,-0.028 6,5 148/150 K,S,L,M,Q,W,G,E,A,T,R,I 171 Y TYR171:A 0.407 3 0.085, 0.535 5,3 148/150 I,F,C,K,H,Y,L 172 L LEU172:A -0.707 8 -0.846,-0.645 8,8 148/150 I,M,V,L 173 K LYS173:A 0.326 4 0.085, 0.535 5,3 147/150 Q,S,K,A,R,T,E,G,N,D 174 N ASN174:A 0.713 2 0.363, 1.008 4,1 147/150 K,H,S,L,M,C,F,Y,D,N,R,T,I 175 G GLY175:A -0.941 9 -1.043,-0.890 9,8 147/150 E,R,G,S 176 N ASN176:A -0.060 5 -0.307, 0.085 6,5 145/150 K,G,N,E,T,Q,R 177 A ALA177:A -0.065 5 -0.307, 0.085 6,5 145/150 Q,L,S,H,K,T,A,E,N,D,G 178 T THR178:A -0.074 5 -0.307, 0.085 6,5 143/150 I,A,R,T,E,D,Q,M,V,H,S,K 179 L LEU179:A -0.793 8 -0.931,-0.700 9,8 144/150 F,R,A,Q,L 180 L LEU180:A 0.163 4 -0.131, 0.363 6,4 144/150 Q,M,S,K,V,L,T,R,E,G,N,D 181 R ARG181:A -0.870 8 -0.971,-0.800 9,8 144/150 G,T,R,H,S,K,L,Q,C 182 T THR182:A -0.287 6 -0.457,-0.224 7,6 138/150 R,T,A,P,S,K,L,Q 183 D ASP183:A -0.505 7 -0.700,-0.386 8,7 135/150 D,V,K,I,A,E 184 S SER184:A 0.059 5 -0.224, 0.214 6,4 135/150 P,T,A,R,N,Q,C,H,S,L,V 185 P PRO185:A -1.120 9 -1.191,-1.077 9,9 135/150 A,P 186 K LYS186:A 0.226 4 -0.028, 0.363 5,4 133/150 D,N,E,A,R,T,L,V,K,H,S,M,Q 187 A ALA187:A -0.572 7 -0.700,-0.457 8,7 133/150 L,V,M,T,A,I 188 H HIS188:A -0.348 6 -0.524,-0.224 7,6 132/150 Y,A,R,T,E,S,H,K,L,V,Q,F 189 V VAL189:A -0.703 8 -0.846,-0.645 8,8 131/150 L,V,G,I,M 190 T THR190:A -0.766 8 -0.890,-0.700 8,8 131/150 R,T,A,N,Y,F,W,L,S 191 H HIS191:A -0.168 6 -0.386,-0.028 7,5 131/150 R,N,D,G,C,Q,L,H,S,K 192 H HIS192:A -0.478 7 -0.645,-0.386 8,7 131/150 K,H,M,Q,D,N,Y,E,R 193 S SER193:A 0.510 3 0.214, 0.744 4,2 131/150 K,S,H,V,L,M,Q,D,E,P,T,R,A 194 R ARG194:A 0.784 2 0.363, 1.008 4,1 131/150 F,Q,L,V,K,H,S,I,P,E,R,A,T,N,G 195 P PRO195:A -0.210 6 -0.457,-0.131 7,6 117/150 T,R,A,P,Y,G,Q,M,F,S,H,V,L 196 E GLU196:A 0.096 5 -0.224, 0.214 6,4 111/150 K,H,L,F,G,Y,D,N,P,E 197 D ASP197:A 0.037 5 -0.224, 0.214 6,4 113/150 G,D,R,E,H,K,L,Q,W 198 K LYS198:A 0.766 2 0.363, 1.008 4,1 112/150 M,Q,V,L,K,I,X,E,A,T,R,D,N,G,Y 199 V VAL199:A -0.504 7 -0.645,-0.386 8,7 131/150 L,V,K,S,F,M,I,P,E,A,T 200 T THR200:A -0.704 8 -0.846,-0.645 8,8 131/150 M,Q,K,S,V,E,P,A,T,R,I 201 L LEU201:A -0.993 9 -1.109,-0.931 9,9 131/150 H,L,V,M,I 202 R ARG202:A -0.335 6 -0.524,-0.224 7,6 131/150 T,A,R,I,Q,C,F,K,H,S,L,V 203 C CYS203:A -1.150 9 -1.201,-1.138 9,9 131/150 C 204 W TRP204:A -0.416 7 -0.645,-0.307 8,6 131/150 L,H,F,M,Q,W,R 205 A ALA205:A -0.867 8 -0.971,-0.800 9,8 131/150 M,A,T,G,S,V,L 206 L LEU206:A -0.477 7 -0.645,-0.386 8,7 131/150 D,Y,T,L,S,H,Q,M 207 G GLY207:A -0.371 6 -0.586,-0.224 7,6 131/150 R,G,K,S,H,D,N 208 F PHE208:A -1.154 9 -1.201,-1.138 9,9 128/150 F 209 Y TYR209:A -0.833 8 -0.971,-0.751 9,8 128/150 F,S,H,Y 210 P PRO210:A -1.117 9 -1.191,-1.077 9,9 128/150 S,P 211 A ALA211:A -0.181 6 -0.386,-0.028 7,5 126/150 P,E,A,R,D,N,G,W,Q,K,S 212 D ASP212:A 0.257 4 -0.028, 0.363 5,4 126/150 M,S,K,R,A,T,P,E,I,G,N,D 213 I ILE213:A -1.011 9 -1.109,-0.971 9,9 126/150 I,A,V 214 T THR214:A 0.133 4 -0.131, 0.214 6,4 126/150 D,G,I,T,R,A,E,V,S,H,M 215 L LEU215:A -0.604 7 -0.751,-0.524 8,7 126/150 V,L,M,A,I 216 T THR216:A -0.468 7 -0.645,-0.386 8,7 126/150 L,V,K,H,S,F,N,I,R,T 217 W TRP217:A -1.111 9 -1.191,-1.077 9,9 126/150 W 218 Q GLN218:A -0.355 6 -0.524,-0.224 7,6 126/150 I,R,T,Y,M,W,Q,L,V,K,H 219 L LEU219:A -0.460 7 -0.645,-0.386 8,7 126/150 L,K,H,W,Q,R 220 N ASN220:A -0.529 7 -0.700,-0.457 8,7 126/150 E,A,K,G,D,N 221 G GLY221:A -0.696 8 -0.846,-0.586 8,7 125/150 D,G,E,R 222 E GLU222:A -0.214 6 -0.457,-0.131 7,6 125/150 V,S,K,Q,M,N,D,A,T,R,E 223 E GLU223:A -0.063 5 -0.307, 0.085 6,5 123/150 D,N,P,E,A,I,K,V,L 224 L LEU224:A 0.327 4 -0.028, 0.535 5,3 122/150 L,V,H,K,F,Q,W,M,D,I,R 225 I ILE225:A -0.272 6 -0.457,-0.131 7,6 124/150 L,V,K,S,H,D,G,I,P,E,T,A 226 Q GLN226:A -0.622 7 -0.800,-0.524 8,7 125/150 M,Q,K,H,S,V,L,E,P,G,D 227 D ASP227:A -0.504 7 -0.700,-0.386 8,7 124/150 Q,S,K,A,E,Y,G,N,D 228 M MET228:A -0.513 7 -0.645,-0.386 8,7 125/150 M,S,K,V,L,T,A,E,I,Y,D 229 E GLU229:A -0.134 6 -0.386,-0.028 7,5 124/150 E,A,R,I,G,D,Q,F,K,H,S,L 230 L LEU230:A 0.558 3 0.214, 0.744 4,2 121/150 Q,W,M,F,C,H,S,K,V,L,R,A,T,P,Y 231 V VAL231:A -0.458 7 -0.645,-0.386 8,7 124/150 T,R,E,I,G,W,M,S,K,V 232 E GLU232:A -0.419 7 -0.586,-0.307 7,6 124/150 S,H,W,D,G,A,P,E 233 T THR233:A -0.677 8 -0.800,-0.586 8,7 124/150 G,L,V,T,M,I 234 R ARG234:A -0.675 8 -0.846,-0.586 8,7 124/150 Q,M,F,V,L,R,A,P,I,G 235 P PRO235:A -0.919 9 -1.043,-0.846 9,8 124/150 H,I,P,Q,T 236 A ALA236:A -0.596 7 -0.751,-0.524 8,7 124/150 N,G,I,E,T,A,V,S,H 237 G GLY237:A -0.559 7 -0.751,-0.457 8,7 124/150 L,V,S,H,Q,D,N,G,P,E,A 238 D ASP238:A -1.073 9 -1.138,-1.043 9,9 124/150 N,D,G 239 G GLY239:A -0.895 8 -1.008,-0.800 9,8 124/150 G,D,N,R 240 T THR240:A -1.023 9 -1.109,-0.971 9,9 124/150 T,N,S 241 F PHE241:A -0.938 9 -1.043,-0.890 9,8 124/150 F,Y 242 Q GLN242:A -1.009 9 -1.109,-0.971 9,9 124/150 Q,L,N,H,Y 243 K LYS243:A -0.556 7 -0.700,-0.457 8,7 123/150 S,K,V,L,M,Y,T,A,R,I 244 W TRP244:A -0.116 5 -0.386, 0.085 7,5 123/150 R,T,A,K,S,M,Q,W 245 A ALA245:A -0.478 7 -0.645,-0.386 8,7 123/150 G,S,L,V,T,A,I 246 S SER246:A -0.398 7 -0.586,-0.307 7,6 123/150 I,E,R,A,T,D,N,V,L,H,S 247 V VAL247:A -0.624 7 -0.751,-0.524 8,7 123/150 I,A,T,L,V 248 V VAL248:A -0.283 6 -0.457,-0.131 7,6 121/150 E,R,T,A,G,D,N,M,Q,K,S,V,L 249 V VAL249:A -0.701 8 -0.846,-0.645 8,8 121/150 V,L,I,Q,A,M 250 P PRO250:A -0.160 6 -0.386,-0.028 7,5 121/150 L,S,K,Q,D,G,T,R,P 251 L LEU251:A -0.395 7 -0.586,-0.307 7,6 120/150 N,R,A,T,P,L,S,F 252 G GLY252:A -0.372 6 -0.586,-0.224 7,6 120/150 Q,V,H,S,K,R,E,D,G 253 K LYS253:A -0.531 7 -0.700,-0.457 8,7 120/150 Q,T,E,P,S,K,D 254 E GLU254:A -0.038 5 -0.307, 0.085 6,5 120/150 L,K,S,W,Q,D,N,G,E,P,T,R,A 255 Q GLN255:A -0.079 5 -0.307, 0.085 6,5 118/150 Q,S,H,E,T,R,A,I,G,Y,D,N 256 Y TYR256:A -0.046 5 -0.307, 0.085 6,5 118/150 Q,H,S,K,L,T,R,E,P,Y,N,D 257 Y TYR257:A -1.036 9 -1.138,-0.971 9,9 118/150 Y,H,F 258 T THR258:A -0.459 7 -0.645,-0.386 8,7 116/150 S,H,Q,M,F,D,R,T,A,X,E,I 259 C CYS259:A -1.145 9 -1.201,-1.138 9,9 117/150 C 260 H HIS260:A -0.292 6 -0.457,-0.224 7,6 117/150 Y,I,T,R,V,L,S,H,C,Q 261 V VAL261:A -1.054 9 -1.138,-1.008 9,9 117/150 G,L,V,F,I 262 Y TYR262:A -0.499 7 -0.700,-0.386 8,7 114/150 E,Y,G,D,Q,H,K,V 263 H HIS263:A -1.072 9 -1.138,-1.043 9,9 114/150 P,H,L 264 Q GLN264:A -0.193 6 -0.386,-0.028 7,5 114/150 T,A,P,E,I,N,D,Q,C,S,K,V 265 G GLY265:A -0.618 7 -0.800,-0.524 8,7 113/150 A,D,G,S 266 L LEU266:A -0.829 8 -0.971,-0.751 9,8 109/150 S,K,V,L,M,I 267 P PRO267:A 0.620 3 0.214, 0.744 4,2 106/150 Q,F,S,K,L,T,A,R,P,E,G,N,D 268 E GLU268:A -0.454 7 -0.645,-0.307 8,6 106/150 M,E,Q,A,K,H,D 269 P PRO269:A -0.554 7 -0.751,-0.457 8,7 104/150 D,P,E,A,T,K,S,L 270 L LEU270:A -0.320 6 -0.586,-0.131 7,6 102/150 M,F,L,V,T,R,I,G 271 T THR271:A -0.117 5 -0.386,-0.028 7,5 100/150 A,R,T,I,D,N,S,V,L 272 L LEU272:A -0.606 7 -0.800,-0.457 8,7 95/150 Y,A,L,V,S,H,F,Q 273 R ARG273:A -0.374 6 -0.586,-0.224 7,6 92/150 N,P,T,R,A,V,L,K,S,Q 274 W TRP274:A -1.075 9 -1.191,-1.043 9,9 91/150 W *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.