The ConSurf Server

Server for the Identification of Functional Regions in Proteins
Version 3.0 now with Jmol Viewer (Sep-06)

What's New in ConSurf 3.0?


Results will be kept on the server for two months.
For further use please save data locally.

ConSurf: the projection of evolutionary conservation scores of residues on protein structures
Landau M., Mayrose I., Rosenberg Y., Glaser F., Martz E., Pupko T., and Ben-Tal N.
Nucl. Acids Res. 33:W299-W302. (2005) PDF.
Bioinformatics 19: 163-164. (2003) PDF.

Method of calculating the amino acid conservation scores (obligatory)

Protein Structure (obligatory)
Enter the PDB ID:
Enter your own PDB file
Chain Identifier

Looking for a PDB ID? Try our pre-calculated ConSurf DataBase

User-Provided Multiple Sequence Alignment (optional)
Enter your own MSA file
Query sequence name in MSA file

User-Provided TREE file (optional)
Enter your own TREE file (in Newick format)

Please enter your e-mail address:
We will use this address in case your job has exceeded its maximal running time.

Send a link to the results by e-mail
Providing your e-mail address ensures that you don't lose the URL to your results.

Advanced Options
Running Parameters (Irrelevant when uploading users MSA)
Build Multiple Sequence Alignment using
Collect the Homologues from
Max. Number of Homologues
No. of PSI-BLAST Iterations
PSI-BLAST E-value Cutoff

Model of substitution for proteins