Amino Acid Conservation Scores =============================== - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - B/E: Burried (b) or Exposed (e) residue. - FUNCTION: functional (f) or structural (s) residue (f - highly conserved and exposed, s - highly conserved and burried). - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS B/E FUNCTION MSA DATA RESIDUE VARIETY (normalized) 1 M -1.205 9 -1.324,-1.134 9,9 e f 88/150 V,L,M 2 A -0.756 8 -0.941,-0.663 8,7 e f 109/150 V,W,T,M,A,S 3 L 0.993 2 0.515, 1.284 3,1 e 111/150 P,C,L,I,Q,F,S,V,A 4 W -0.266 6 -0.663,-0.030 7,5 b 111/150 M,G,L,W,R 5 M 0.651 3 0.206, 0.957 4,2 b 111/150 V,A,F,L,I,M,T,P,N 6 R -0.385 6 -0.663,-0.224 7,6 e 110/150 Q,S,H,A,P,C,R,E 7 L -0.291 6 -0.534,-0.132 7,5 b 112/150 F,S,G,A,V,C,T,I,L 8 L 0.223 4 -0.132, 0.515 5,3 b 118/150 F,A,G,V,R,T,L,I 9 P -0.126 5 -0.390, 0.082 6,5 e 122/150 H,F,S,V,A,P,L,T 10 L -0.329 6 -0.601,-0.132 7,5 b 139/150 V,I,L,M,A 11 L -0.545 7 -0.781,-0.390 8,6 b 140/150 L,I,V,T,M,A,F 12 A 0.202 4 -0.132, 0.348 5,4 b 141/150 S,F,V,A,R,L,D,I,T 13 L -0.768 8 -0.991,-0.663 8,7 b 141/150 M,L,I,V,F 14 L -0.157 6 -0.464, 0.082 7,5 b 141/150 M,A,V,I,L,C,F 15 A 0.524 3 0.206, 0.711 4,3 b 141/150 G,A,V,F,S,T,M,D,L,I 16 L 0.448 3 0.082, 0.711 5,3 b 140/150 W,L,I,M,T,R,V,A,G,F 17 W -0.202 6 -0.464,-0.030 7,5 b 137/150 T,W,L,C,R,P,A,G,H,S,F,Y 18 G 1.285 1 0.711, 1.785 3,1 e 142/150 D,P,C,R,V,A,G,S,F,I,W,L,T,E,Q,Y 19 P -0.386 6 -0.663,-0.224 7,6 e 143/150 H,S,A,V,R,P,T,L 20 D 2.322 1 1.284, 3.091 1,1 e 139/150 F,H,S,V,A,G,P,N,C,R,D,K,Q,X,E,W,I,L,M,T 21 P 0.302 4 -0.030, 0.515 5,3 e 99/150 S,H,V,G,A,P,I,T 22 A 0.262 4 -0.030, 0.515 5,3 e 142/150 V,G,A,Q,S,L,D,T,M,P,R,N 23 A 1.447 1 0.957, 1.785 2,1 e 142/150 P,E,R,N,C,D,L,T,K,Y,Q,S,H,G,A 24 A -0.170 6 -0.390,-0.030 6,5 e 144/150 P,I,L,M,T,Q,S,F,V,A,G 25 F 1.533 1 0.957, 1.785 2,1 e 145/150 T,L,I,D,R,E,P,A,G,V,S,F,Q,Y 26 V 0.330 4 -0.030, 0.515 5,3 e 144/150 N,P,T,L,D,S,Y,A,G,V 27 N 0.576 3 0.206, 0.711 4,3 e 147/150 V,A,F,H,S,I,L,D,T,K,P,E,N 28 Q -0.753 8 -0.941,-0.663 8,7 e f 150/150 Q,Y,H,R,E,K,G 29 H -0.692 7 -0.889,-0.601 8,7 e 150/150 R,H,Y 30 L -1.270 9 -1.379,-1.228 9,9 b s 150/150 L,F 31 C -1.316 9 -1.415,-1.275 9,9 b s 150/150 C 32 G -1.266 9 -1.379,-1.228 9,9 e f 150/150 G,D 33 S -0.623 7 -0.781,-0.534 8,7 e 150/150 P,R,E,D,K,T,S,H,V,A 34 H -0.852 8 -0.991,-0.781 8,8 e f 150/150 R,E,S,H,N,Q,D 35 L -1.329 9 -1.415,-1.324 9,9 b s 150/150 L 36 V -1.257 9 -1.379,-1.228 9,9 b s 150/150 L,V,A 37 E -0.522 7 -0.724,-0.390 7,6 e 150/150 D,K,E,N 38 A -1.147 9 -1.275,-1.087 9,9 b s 150/150 T,M,A,I,S 39 L -1.201 9 -1.324,-1.134 9,9 b s 150/150 F,M,L 40 Y 0.035 5 -0.310, 0.206 6,4 b 150/150 T,L,I,N,R,A,V,H,F,Y 41 L 0.016 5 -0.310, 0.206 6,4 b 150/150 M,V,I,L,F,S,R 42 V -0.813 8 -0.991,-0.724 8,7 b 150/150 V,L,I,T,A 43 C -1.316 9 -1.415,-1.275 9,9 b s 150/150 C 44 G -1.264 9 -1.379,-1.228 9,9 e f 150/150 G,Q 45 E 0.126 5 -0.224, 0.348 6,4 e 149/150 A,D,V,R,E,S,P 46 R -0.305 6 -0.534,-0.132 7,5 e 149/150 T,K,D,R,N,S,Q 47 G -1.326 9 -1.415,-1.275 9,9 b s 150/150 G 48 F -1.190 9 -1.324,-1.134 9,9 b s 149/150 F,L 49 F -0.462 7 -0.724,-0.310 7,6 e 145/150 Y,S,F,L,I,T 50 Y -0.513 7 -0.781,-0.390 8,6 e 150/150 F,H,Y,A,R,N,K,W 51 T 0.484 3 0.082, 0.711 5,3 e 150/150 S,Q,Y,A,G,N,R,E,K,M,T,I,D 52 P -0.903 8 -1.087,-0.781 9,8 e f 150/150 R,N,S,P,Q 53 K 1.003 2 0.515, 1.284 3,1 e 118/150 H,S,Q,G,R,N,T,K,M,D 54 T 1.154 1 0.711, 1.284 3,1 e 116/150 F,H,S,Q,G,A,V,R,E,T,M,K,D 55 R -0.393 6 -0.601,-0.224 7,6 e 147/150 G,A,T,K,M,L,I,R,E,N,P,X 56 R -1.093 9 -1.228,-1.039 9,9 e f 146/150 G,T,L,R,S,N,X 57 E -0.004 5 -0.310, 0.206 6,4 e 149/150 N,E,P,D,I,S,A,G 58 A 1.050 1 0.515, 1.284 3,1 b 149/150 Q,Y,V,A,N,R,L,I,M,T 59 E 0.239 4 -0.132, 0.515 5,3 e 149/150 A,G,H,Q,K,T,D,N,R,E,P 60 D 0.563 3 0.206, 0.711 4,3 e 150/150 D,T,P,N,E,R,A,G,Q,H,S 61 L 0.893 2 0.515, 1.284 3,1 b 150/150 Q,S,V,G,A,P,L,D,I,T,M 62 Q 0.147 5 -0.132, 0.348 5,4 e 149/150 S,F,Q,A,X,P,M,T,L,I 63 V 0.976 2 0.515, 1.284 3,1 e 143/150 T,M,I,L,E,R,X,P,G,A,V,S,Y 64 G 1.922 1 1.284, 1.785 1,1 e 142/150 P,X,N,R,E,D,K,T,Q,S,V,A,G 65 Q 1.888 1 0.957, 1.785 2,1 e 101/150 E,R,P,X,T,M,D,S,Q,G,A,V 66 V 2.157 1 1.284, 3.091 1,1 e 90/150 X,P,E,L,M,T,S,F,H,V,A,G 67 E 1.030 2 0.348, 1.284 4,1 e 46/150 Q,S,G,A,X,E,R,L,D 68 L 1.763 1 0.957, 1.785 2,1 e 131/150 M,T,L,E,Q,Y,K,D,N,C,R,P,A,G,V,H,S,F 69 G 1.747 1 0.957, 1.785 2,1 e 127/150 H,S,F,Q,Y,A,G,E,R,P,K,D,W,L 70 G 0.541 3 0.206, 0.711 4,3 e 128/150 M,K,T,P,N,E,R,V,A,G,Q,S 71 G 0.565 3 0.206, 0.711 4,3 e 125/150 S,Q,G,A,V,R,E,P,K,D,W 72 P 0.495 3 0.082, 0.711 5,3 e 119/150 T,M,K,L,E,R,P,G,A,V,H,S 73 G 1.111 1 0.515, 1.284 3,1 e 136/150 K,M,T,L,D,I,C,N,E,R,P,A,G,V,Q 74 A 0.689 3 0.348, 0.957 4,2 e 135/150 I,L,W,D,T,K,E,R,V,G,A,Q,S 75 G 1.115 1 0.515, 1.284 3,1 e 140/150 G,A,V,H,F,S,Y,Q,M,K,L,D,R,N 76 S 1.060 1 0.515, 1.284 3,1 e 144/150 T,K,D,L,R,E,P,G,A,V,F,S,Q 77 L 2.278 1 1.284, 3.091 1,1 e 142/150 V,A,Q,Y,F,S,H,I,L,W,K,M,P,R,E 78 Q -0.041 5 -0.310, 0.082 6,5 e 143/150 D,I,L,M,K,P,E,R,N,A,Q,S,F 79 P 1.117 1 0.711, 1.284 3,1 e 139/150 H,S,Q,A,G,V,N,E,P,K,T,D 80 L 0.609 3 0.206, 0.957 4,2 e 137/150 L,I,M,K,T,R,E,A,G,Q,Y,H,F,S 81 A 0.719 3 0.206, 0.957 4,2 e 83/150 E,N,C,P,T,M,L,D,S,G,A 82 L 1.433 1 0.957, 1.785 2,1 e 141/150 N,E,R,D,I,L,M,T,Q,Y,S,F,V,A,G 83 E 0.184 4 -0.132, 0.348 5,4 e 113/150 M,K,D,E,G,A,V,S,H,Q 84 G 2.585 1 1.284, 3.091 1,1 e 49/150 L,V,M,A,G,Q,E 85 S 1.402 1 0.957, 1.785 2,1 e 136/150 G,A,V,H,S,Q,T,M,I,L,E,R,P 86 L 0.702 3 0.348, 0.957 4,2 e 133/150 Q,V,A,P,R,I,L,K,M 87 Q -0.067 5 -0.310, 0.082 6,5 e 145/150 A,V,S,Q,T,M,K,L,I,R,E 88 K -0.933 8 -1.087,-0.836 9,8 e f 144/150 E,R,N,X,Q,A,K 89 R -1.178 9 -1.324,-1.134 9,9 e f 144/150 P,X,S,R,T 90 G -1.068 9 -1.228,-0.991 9,8 e f 146/150 D,G,N,S 91 I -1.301 9 -1.379,-1.275 9,9 b s 147/150 I,V 92 V -1.254 9 -1.379,-1.228 9,9 b s 147/150 M,I,L,V 93 E -0.454 7 -0.663,-0.310 7,6 e 147/150 E,Q,D 94 Q -0.674 7 -0.836,-0.534 8,7 e 147/150 H,E,R,Q,M,L,V 95 C -1.315 9 -1.415,-1.275 9,9 b s 147/150 C 96 C -1.243 9 -1.379,-1.181 9,9 b s 147/150 T,C 97 T -0.239 6 -0.464,-0.132 7,5 e 147/150 Y,Q,S,H,V,A,E,N,D,L,T 98 S 0.256 4 -0.030, 0.515 5,3 e 147/150 T,M,K,R,N,G,F,H,S,Q 99 I -0.088 5 -0.390, 0.082 6,5 e 147/150 L,I,T,P,R,V,Y,F,S 100 C -1.315 9 -1.415,-1.275 9,9 b s 147/150 C 101 S -0.762 8 -0.941,-0.663 8,7 e f 147/150 T,D,N,S,P 102 L -0.463 7 -0.663,-0.310 7,6 b 147/150 L,V,I,Y,R,F 103 Y 0.397 4 -0.030, 0.711 5,3 e 147/150 V,A,Y,F,S,H,L,P,N,E 104 Q -0.390 6 -0.601,-0.224 7,6 e 147/150 E,H,N,Q,V,D 105 L -1.198 9 -1.324,-1.134 9,9 b s 146/150 M,L,Q 106 E -0.328 6 -0.534,-0.132 7,5 e 147/150 E,N,S,Q,G,K,A 107 N -0.254 6 -0.464,-0.132 7,5 e 147/150 Q,Y,H,S,G,N,E,R,D,K,T 108 Y -1.255 9 -1.379,-1.181 9,9 e f 147/150 Y,F 109 C -1.315 9 -1.415,-1.275 9,9 e f 147/150 C 110 N -1.015 8 -1.134,-0.941 9,8 e f 142/150 P,H,S,N,D *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.