Amino Acid Conservation Scores ======================================= - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 M MET1:A -1.099 9 -1.113,-1.094 9,9 108/150 M 2 K LYS2:A -0.226 6 -0.441,-0.118 7,5 116/150 K,S,E,N,H,L,Q,R 3 F PHE3:A -0.271 6 -0.441,-0.212 7,6 119/150 I,V,F,A,L,Y 4 T THR4:A 0.076 5 -0.118, 0.257 5,4 123/150 I,N,E,A,Q,L,D,V,K,S,T 5 V VAL5:A -0.143 6 -0.297,-0.011 6,5 138/150 A,L,M,I,F,S,T,V 6 E GLU6:A 0.478 3 0.112, 0.655 5,2 143/150 N,E,I,P,R,Q,L,A,K,D,T,S,G 7 R ARG7:A -0.877 9 -0.960,-0.832 9,8 144/150 K,N,V,R,Q 8 E GLU8:A 0.028 5 -0.212, 0.112 6,5 146/150 E,N,A,Q,K,D,V,T,G,S 9 H HIS9:A 0.991 1 0.655, 0.958 2,1 147/150 P,E,F,A,L,Q,D,V,T,I,N,H,R,K,S,G 10 L LEU10:A -0.551 7 -0.665,-0.504 8,7 147/150 L,M,V,I,F 11 L LEU11:A -0.607 7 -0.754,-0.562 8,7 147/150 I,H,A,Q,L,V,W,T 12 K LYS12:A 0.137 4 -0.118, 0.257 5,4 147/150 T,G,S,K,V,D,Y,R,H,A,Q,N,E,P 13 P PRO13:A -0.301 6 -0.504,-0.212 7,6 147/150 R,H,L,A,N,I,P,T,G,S,C,V 14 L LEU14:A -0.932 9 -1.013,-0.900 9,9 147/150 V,I,L,M 15 Q GLN15:A -0.392 7 -0.562,-0.297 7,6 147/150 V,K,S,G,T,N,Q,A,L,M 16 Q GLN16:A -0.179 6 -0.372,-0.118 7,5 147/150 T,S,K,V,M,Y,R,A,H,Q,L,F,N,I 17 V VAL17:A -0.774 8 -0.867,-0.711 9,8 147/150 V,I,L,A 18 S SER18:A -0.202 6 -0.372,-0.118 7,5 147/150 L,H,Q,A,Y,I,N,E,G,S,C,T,V,K 19 G GLY19:A -0.576 7 -0.711,-0.504 8,7 147/150 L,A,S,G,R,N,K 20 P PRO20:A -0.800 8 -0.900,-0.754 9,8 147/150 A,L,P,I,F,S,G,T,V 21 L LEU21:A -0.864 9 -0.931,-0.832 9,8 147/150 V,I,S,A,L,T 22 G GLY22:A -0.870 9 -0.960,-0.832 9,8 147/150 T,S,G,V,D,A,E,I 23 G GLY23:A -0.489 7 -0.615,-0.441 8,7 147/150 K,N,P,R,Q,S,G 24 R ARG24:A -0.856 9 -0.931,-0.794 9,8 147/150 R,G,N,K 25 P PRO25:A -0.636 8 -0.754,-0.562 8,7 147/150 T,S,Q,H,L,A,N,I,P 26 T THR26:A -0.871 9 -0.931,-0.832 9,8 148/150 I,N,A,L,S,T 27 L LEU27:A -0.696 8 -0.794,-0.615 8,8 149/150 A,L,M,Y,I,F,T,V,K 28 P PRO28:A -0.700 8 -0.832,-0.615 8,8 149/150 V,P,N,K,Q,A,T 29 I ILE29:A -0.941 9 -1.013,-0.900 9,9 149/150 V,I 30 L LEU30:A -1.073 9 -1.108,-1.058 9,9 149/150 I,L 31 G GLY31:A -0.559 7 -0.665,-0.504 8,7 149/150 G,A,S,N,E 32 N ASN32:A -1.038 9 -1.077,-1.013 9,9 149/150 N,H,C,Y 33 L LEU33:A -0.502 7 -0.615,-0.441 8,7 149/150 V,I,F,L,T,M 34 L LEU34:A -0.830 8 -0.931,-0.794 9,8 149/150 M,R,L,F,K 35 L LEU35:A 0.066 5 -0.118, 0.257 5,4 149/150 F,V,I,M,L 36 Q GLN36:A 0.877 1 0.434, 0.958 3,1 149/150 I,E,N,A,H,Q,R,D,V,K,C,S,G,T 37 V VAL37:A -0.117 5 -0.297,-0.011 6,5 149/150 H,Q,A,L,R,P,I,F,G,S,T,V,K 38 A ALA38:A 2.104 1 0.958, 2.689 1,1 149/150 S,G,T,D,K,A,H,Q,R,I,E,F,N 39 D ASP39:A 1.268 1 0.655, 1.425 2,1 149/150 H,A,Q,R,P,N,E,G,S,T,D,K 40 G GLY40:A 1.359 1 0.958, 1.425 1,1 149/150 E,N,I,P,A,Q,H,K,D,T,S,G 41 T THR41:A 2.683 1 1.425, 2.689 1,1 149/150 W,K,C,S,G,I,N,H,R,Y,V,D,T,F,E,L,A,Q,M 42 L LEU42:A -0.350 6 -0.504,-0.297 7,6 149/150 I,V,M,T,L,A 43 S SER43:A 0.793 2 0.434, 0.958 3,1 149/150 M,A,Q,L,E,T,V,D,Y,R,H,N,I,S,G,W,K 44 L LEU44:A -0.096 5 -0.297,-0.011 6,5 149/150 F,V,I,M,L 45 T THR45:A -0.653 8 -0.754,-0.615 8,8 149/150 L,A,M,R,I,N,E,S,T,V,D,K 46 G GLY46:A -0.556 7 -0.665,-0.504 8,7 149/150 T,G,S,A 47 T THR47:A -1.028 9 -1.077,-1.013 9,9 149/150 N,T,S 48 D ASP48:A -1.036 9 -1.077,-1.013 9,9 149/150 D,N 49 L LEU49:A -0.806 8 -0.900,-0.754 9,8 149/150 I,T,M,S,Q,L,A 50 E GLU50:A -0.937 9 -1.013,-0.900 9,9 149/150 D,E 51 M MET51:A -0.374 7 -0.504,-0.297 7,6 149/150 I,V,M,R,T,A,L 52 E GLU52:A -0.881 9 -0.960,-0.832 9,8 149/150 A,Q,E,D 53 M MET53:A -0.435 7 -0.562,-0.372 7,7 149/150 I,V,W,A,L,M,T 54 V VAL54:A 0.238 4 -0.011, 0.434 5,3 149/150 T,S,G,K,D,V,M,R,Q,H,A,L,E,I 55 A ALA55:A -0.240 6 -0.441,-0.118 7,5 149/150 G,C,S,T,D,V,K,A,H,L,I,E 56 R ARG56:A 1.274 1 0.655, 1.425 2,1 149/150 I,N,H,R,Y,K,C,S,G,F,E,L,A,Q,D,V,T 57 V VAL57:A 0.307 4 -0.011, 0.434 5,3 149/150 Q,H,L,A,I,F,G,C,S,T,V 58 A ALA58:A 2.683 1 1.425, 2.689 1,1 149/150 Q,L,H,A,N,E,P,I,T,S,G,K,V,D 59 L LEU59:A 0.352 4 0.112, 0.434 5,3 149/150 L,Q,A,M,P,E,F,T,V,D,Y,I,G,S,C,K 60 V VAL60:A 2.060 1 0.958, 2.689 1,1 149/150 S,G,K,H,I,N,T,D,V,Q,A,L,M,P,F,E 61 Q GLN61:A 0.816 2 0.434, 0.958 3,1 149/150 E,N,I,R,H,A,L,Q,K,D,V,T,C,S,G 62 P PRO62:A 2.628 1 1.425, 2.689 1,1 149/150 N,I,H,K,S,C,G,E,F,P,L,A,Q,V,D,T 63 H HIS63:A 1.353 1 0.655, 1.425 2,1 80/150 T,S,C,G,D,V,Y,L,A,Q,H,E,N,F 64 E GLU64:A 1.492 1 0.958, 1.425 1,1 149/150 K,S,G,I,N,H,R,D,V,T,P,E,F,A,Q,M 65 P PRO65:A 2.339 1 0.958, 2.689 1,1 149/150 Q,A,I,P,F,E,N,G,S,T,V,D,K 66 G GLY66:A -0.050 5 -0.297, 0.112 6,5 149/150 I,F,E,L,Q,H,A,Y,R,V,K,S,C,G,T 67 A ALA67:A 0.663 2 0.257, 0.958 4,1 149/150 P,I,E,N,A,Q,R,D,V,K,G,S,T 68 T THR68:A 0.067 5 -0.118, 0.112 5,5 149/150 L,A,F,I,T,S,C,V 69 T THR69:A -1.072 9 -1.108,-1.058 9,9 149/150 V,A,T 70 V VAL70:A -0.635 8 -0.754,-0.562 8,7 149/150 T,A,L,V,I 71 P PRO71:A -0.339 6 -0.504,-0.212 7,6 149/150 G,A,Q,S,P,N 72 A ALA72:A -0.883 9 -0.960,-0.832 9,8 149/150 V,G,A,C,S 73 R ARG73:A -0.403 7 -0.562,-0.297 7,6 149/150 G,S,V,D,K,L,A,Q,H,R,Y,I,N 74 K LYS74:A -0.847 8 -0.931,-0.794 9,8 149/150 M,T,L,K,V 75 F PHE75:A -0.609 7 -0.754,-0.562 8,7 149/150 L,W,F,I 76 F PHE76:A 0.035 5 -0.212, 0.112 6,5 149/150 S,T,V,K,Q,H,A,L,Y,R,M,I,F,N 77 D ASP77:A -0.799 8 -0.900,-0.754 9,8 149/150 T,S,N,E,D 78 I ILE78:A -1.037 9 -1.077,-1.013 9,9 149/150 L,V,I,F 79 C CYS79:A -0.504 7 -0.615,-0.441 8,7 149/150 I,A,L,W,V,T,C,S 80 R ARG80:A -0.743 8 -0.832,-0.665 8,8 149/150 K,Q,T,R 81 G GLY81:A -0.623 8 -0.754,-0.562 8,7 149/150 K,T,S,G,N,M,L,A 82 L LEU82:A -0.839 8 -0.931,-0.794 9,8 149/150 I,F,A,L,S,M 83 P PRO83:A -0.059 5 -0.297, 0.112 6,5 149/150 E,N,P,R,A,Q,L,K,D,T,G,S 84 E GLU84:A 0.643 2 0.257, 0.655 4,2 149/150 T,S,G,K,D,Y,H,L,A,N,E,P 85 G GLY85:A 0.932 1 0.434, 0.958 3,1 148/150 A,L,H,Q,E,N,S,G,T,D,K 86 A ALA86:A -0.096 5 -0.297,-0.011 6,5 149/150 G,S,C,T,V,L,H,Q,A,I,N 87 E GLU87:A 1.931 1 0.958, 2.689 1,1 149/150 N,I,R,K,S,G,F,E,P,M,Q,A,L,D,V,T 88 I ILE88:A -0.579 7 -0.711,-0.504 8,7 149/150 L,A,V,P,I 89 A ALA89:A 1.155 1 0.655, 1.425 2,1 149/150 H,R,I,N,S,G,K,L,A,Q,M,F,E,T,V,D 90 V VAL90:A 0.007 5 -0.212, 0.112 6,5 149/150 M,A,L,F,I,V 91 Q GLN91:A 1.926 1 0.958, 2.689 1,1 149/150 S,T,D,V,K,H,Q,L,A,Y,R,M,I,E,N 92 L LEU92:A 0.944 1 0.434, 0.958 3,1 149/150 G,S,C,W,Y,R,H,I,T,V,D,M,A,L,Q,E,F 93 E GLU93:A 1.436 1 0.958, 1.425 1,1 149/150 L,A,Q,P,I,E,N,S,G,T,D,V,K 94 G GLY94:A 1.082 1 0.655, 1.425 2,1 148/150 E,N,P,M,R,H,A,Q,K,V,D,T,S,G 95 E GLU95:A 1.293 1 0.655, 1.425 2,1 148/150 E,N,P,R,H,Q,A,K,V,D,T,G,S 96 R ARG96:A 0.091 5 -0.118, 0.257 5,4 150/150 A,Q,R,P,I,N,G,S,T,V,K,W 97 M MET97:A 0.418 3 0.112, 0.655 5,2 150/150 M,A,L,F,I,C,W,V 98 L LEU98:A 1.126 1 0.655, 1.425 2,1 150/150 K,V,T,S,G,E,N,I,M,Y,R,Q,A,H,L 99 V VAL99:A 0.030 5 -0.212, 0.112 6,5 150/150 L,M,I,V 100 R ARG100:A 1.093 1 0.655, 1.425 2,1 150/150 A,H,L,Q,R,I,E,N,F,S,G,T,D,V,K 101 S SER101:A -0.394 7 -0.562,-0.297 7,6 150/150 F,I,Y,L,Q,A,T,G,S,C 102 G GLY102:A -0.550 7 -0.711,-0.441 8,7 150/150 D,K,G,S,P,E,N,H,A,Q 103 R ARG103:A -0.580 7 -0.711,-0.504 8,7 150/150 G,S,C,T,K,A,Q,H,R,N 104 S SER104:A -0.812 8 -0.900,-0.754 9,8 150/150 T,G,S,N,F,I,Y,A 105 R ARG105:A -0.275 6 -0.441,-0.212 7,6 150/150 S,K,R,H,A,Q,N,E 106 F PHE106:A -0.838 8 -0.931,-0.794 9,8 150/150 S,T,Y,F 107 S SER107:A 0.093 5 -0.118, 0.257 5,4 150/150 K,V,T,S,N,E,I,M,R,Q,A,H,L 108 L LEU108:A -1.026 9 -1.077,-1.013 9,9 150/150 V,M,L 109 S SER109:A -0.358 6 -0.504,-0.297 7,6 150/150 T,G,S,V,M,H,L,Q,A,N,P 110 T THR110:A -0.777 8 -0.867,-0.711 9,8 150/150 M,T,A,C,S,L,V 111 L LEU111:A -1.050 9 -1.094,-1.036 9,9 150/150 L,F,I 112 P PRO112:A -0.372 7 -0.562,-0.297 7,6 150/150 T,A,S,N,E,P,D 113 A ALA113:A -0.562 7 -0.665,-0.504 8,7 150/150 P,I,E,L,Q,A,R,V,K,S,G,T 114 A ALA114:A 1.348 1 0.958, 1.425 1,1 150/150 R,H,A,Q,N,E,I,T,G,S,K,D,V 115 D ASP115:A -0.449 7 -0.615,-0.372 8,7 150/150 D,G,S,T,E,N,H,Q 116 F PHE116:A -0.701 8 -0.794,-0.615 8,8 150/150 F,Y 117 P PRO117:A -1.079 9 -1.113,-1.058 9,9 150/150 P 118 N ASN118:A 0.206 4 -0.011, 0.257 5,4 150/150 A,Q,L,H,M,R,I,E,N,S,C,T,D,V,K 119 L LEU119:A -0.019 5 -0.212, 0.112 6,5 150/150 T,C,S,G,W,V,M,H,Q,L,A,N,F,I 120 D ASP120:A 0.233 4 -0.011, 0.434 5,3 150/150 N,E,P,M,A,L,Q,K,D,V,T,S,G 121 D ASP121:A 1.202 1 0.655, 1.425 2,1 150/150 K,S,G,I,N,H,R,V,D,T,P,E,L,A,Q,M 122 W TRP122:A 0.787 2 0.434, 0.958 3,1 150/150 N,I,H,W,S,C,G,F,E,P,A,L,Q,V,D,T 123 Q GLN123:A 2.274 1 0.958, 2.689 1,1 150/150 H,L,A,Q,P,E,N,G,S,T,V,D,K 124 S SER124:A 1.016 1 0.655, 1.425 2,1 150/150 H,Y,R,I,N,S,G,W,L,Q,A,M,P,E,F,T,V,D 125 E GLU125:A 0.815 2 0.434, 0.958 3,1 150/150 K,S,G,I,N,H,Y,R,V,D,T,P,E,A,L,Q,M 126 V VAL126:A 0.638 2 0.257, 0.655 4,2 150/150 P,E,F,A,L,Q,M,V,D,T,I,N,H,Y,R,K,C,S 127 E GLU127:A 1.773 1 0.958, 2.689 1,1 150/150 N,E,I,P,R,A,Q,H,W,K,D,V,T,S,G 128 F PHE128:A -0.102 5 -0.297,-0.011 6,5 150/150 L,M,V,I,F 129 T THR129:A 0.933 1 0.434, 0.958 3,1 150/150 K,V,D,T,G,S,N,F,E,I,P,R,Q,A 130 L LEU130:A 0.165 4 -0.118, 0.257 5,4 150/150 I,V,F,L,A,M,T 131 P PRO131:A 2.684 1 1.425, 2.689 1,1 150/150 T,S,G,K,D,V,M,A,Q,E,N,P,I 132 Q GLN132:A -0.436 7 -0.562,-0.372 7,7 150/150 R,Q,A,H,E,P,T,S,G,K,V 133 A ALA133:A 1.327 1 0.958, 1.425 1,1 150/150 T,G,S,K,D,V,R,H,Q,L,A,N,F,E,P 134 T THR134:A 1.524 1 0.958, 1.425 1,1 150/150 K,D,V,T,S,G,N,E,I,M,R,L,H,A,Q 135 M MET135:A -0.560 7 -0.711,-0.504 8,7 150/150 I,V,F,L,M 136 K LYS136:A 0.054 5 -0.118, 0.112 5,5 150/150 S,K,V,R,A,H,L,N,I 137 R ARG137:A 1.196 1 0.655, 1.425 2,1 150/150 M,Y,R,L,A,H,Q,N,E,T,S,G,K,W,D 138 L LEU138:A -0.762 8 -0.867,-0.711 9,8 150/150 V,I,A,L,M 139 I ILE139:A -0.385 7 -0.504,-0.297 7,6 150/150 V,I,F,L,M 140 E GLU140:A 0.329 4 0.112, 0.434 5,3 150/150 E,F,N,L,H,A,Q,D,K,G,S,C,T 141 A ALA141:A 0.017 5 -0.212, 0.112 6,5 150/150 M,R,L,H,Q,A,F,N,T,C,S,K,D 142 T THR142:A -0.923 9 -0.987,-0.900 9,9 150/150 C,A,S,T,V 143 Q GLN143:A -0.082 5 -0.297,-0.011 6,5 150/150 M,R,Y,A,Q,H,N,E,T,S,G,K,V 144 F PHE144:A -1.004 9 -1.058,-0.987 9,9 150/150 Y,F 145 S SER145:A -0.781 8 -0.867,-0.754 9,8 150/150 C,S,A 146 M MET146:A -1.042 9 -1.077,-1.036 9,9 150/150 M,I,V 147 A ALA147:A -1.037 9 -1.077,-1.013 9,9 150/150 S,A,G,P 148 H HIS148:A -0.536 7 -0.665,-0.441 8,7 150/150 N,I,Q,L,A,H,K,V,T,S 149 Q GLN149:A -0.990 9 -1.036,-0.960 9,9 150/150 Q,A,H,D,E 150 D ASP150:A -1.076 9 -1.108,-1.058 9,9 150/150 D,E 151 V VAL151:A -0.971 9 -1.036,-0.931 9,9 150/150 L,A,T,M,V,I 152 R ARG152:A -1.096 9 -1.113,-1.094 9,9 150/150 R 153 Y TYR153:A -0.912 9 -0.987,-0.867 9,9 150/150 N,F,V,I,Y,S,Q 154 Y TYR154:A -0.918 9 -0.987,-0.867 9,9 150/150 Y,F 155 L LEU155:A -1.094 9 -1.113,-1.094 9,9 150/150 L 156 N ASN156:A -1.070 9 -1.108,-1.058 9,9 150/150 Q,T,N 157 G GLY157:A -1.085 9 -1.113,-1.077 9,9 150/150 G 158 M MET158:A -0.563 7 -0.665,-0.504 8,7 150/150 M,T,L,I,V 159 L LEU159:A -0.725 8 -0.832,-0.665 8,8 150/150 S,H,L,Y,M,F,K 160 F PHE160:A 0.234 4 -0.011, 0.434 5,3 150/150 L,M,I,V,W,F 161 E GLU161:A -0.650 8 -0.754,-0.562 8,7 150/150 D,V,G,S,N,E,I,A,L,H,Q 162 T THR162:A 0.174 4 -0.011, 0.257 5,4 150/150 M,L,A,F,P,I,T,S,C,K,V 163 E GLU163:A 1.088 1 0.655, 1.425 2,1 150/150 F,E,Q,L,A,M,V,D,T,I,N,H,R,K,G,S 164 G GLY164:A 2.641 1 1.425, 2.689 1,1 150/150 A,Q,P,N,E,G,S,T,D,V,K 165 E GLU165:A 1.956 1 0.958, 2.689 1,1 150/150 Q,L,A,P,E,T,V,D,H,Y,R,I,N,G,S,K 166 E GLU166:A 1.771 1 0.958, 2.689 1,1 150/150 N,I,Y,R,H,K,G,C,S,F,E,M,A,Q,L,V,D,T 167 L LEU167:A -0.353 6 -0.504,-0.297 7,6 150/150 F,V,I,M,L,A 168 R ARG168:A -0.335 6 -0.504,-0.212 7,6 150/150 T,S,K,V,R,Y,M,A,Q,H,N,I 169 T THR169:A -0.130 6 -0.297,-0.011 6,5 150/150 V,T,G,C,S,M,L,A 170 V VAL170:A -0.971 9 -1.036,-0.931 9,9 150/150 L,A,V,I 171 A ALA171:A -0.929 9 -0.987,-0.900 9,9 150/150 G,S,A,T 172 T THR172:A -1.088 9 -1.113,-1.077 9,9 150/150 T,S 173 D ASP173:A -1.076 9 -1.108,-1.058 9,9 150/150 N,D 174 G GLY174:A -1.045 9 -1.094,-1.013 9,9 150/150 T,G 175 H HIS175:A -1.066 9 -1.108,-1.058 9,9 150/150 N,Y,H 176 R ARG176:A -1.096 9 -1.113,-1.094 9,9 150/150 R 177 L LEU177:A -0.943 9 -1.013,-0.900 9,9 150/150 I,L,M 178 A ALA178:A -0.915 9 -0.987,-0.867 9,9 150/150 S,A,G 179 V VAL179:A 0.174 4 -0.118, 0.257 5,4 150/150 C,S,T,V,K,Q,H,L,M,R,Y,I,F 180 C CYS180:A 0.062 5 -0.118, 0.112 5,5 150/150 N,F,I,Y,A,L,H,V,T,G,S,C 181 S SER181:A 0.631 2 0.257, 0.655 4,2 150/150 T,C,S,G,K,V,D,R,Y,H,L,Q,A,E,N 182 M MET182:A 1.437 1 0.958, 1.425 1,1 150/150 G,C,S,T,V,D,K,L,Q,A,R,Y,M,I,E 183 P PRO183:A 2.689 1 1.425, 2.689 1,1 150/150 F,N,E,P,I,R,Q,L,A,K,V,D,T,G,S 184 I ILE184:A 0.725 2 0.434, 0.958 3,1 150/150 A,Q,L,M,F,E,T,V,D,R,Y,I,N,S,C,K 185 G GLY185:A 1.377 1 0.958, 1.425 1,1 150/150 H,A,Q,N,E,I,P,T,S,G,K,D 186 Q GLN186:A 2.631 1 1.425, 2.689 1,1 150/150 T,D,V,M,A,L,Q,F,E,S,C,G,K,H,N,I 187 S SER187:A 2.549 1 1.425, 2.689 1,1 150/150 L,Q,A,I,P,F,N,E,G,S,T,V,D,K 188 L LEU188:A 2.544 1 1.425, 2.689 1,1 116/150 R,A,H,Q,L,F,E,P,I,T,S,G,K,V,D 189 P PRO189:A 2.635 1 1.425, 2.689 1,1 150/150 I,N,H,Y,K,G,S,P,E,F,L,A,Q,D,V,T 190 S SER190:A 1.138 1 0.655, 1.425 2,1 150/150 K,S,C,G,I,N,H,R,Y,D,V,T,P,F,E,Q,A,L,M 191 H HIS191:A 0.753 2 0.434, 0.958 3,1 150/150 S,K,H,Y,R,I,N,T,V,A,L,Q,M,P,F,E 192 S SER192:A -0.616 8 -0.711,-0.562 8,7 150/150 E,R,A,Q,K,D,S,G 193 V VAL193:A -0.374 7 -0.504,-0.297 7,6 150/150 R,A,L,F,P,I,S,C,V 194 I ILE194:A -1.090 9 -1.113,-1.077 9,9 150/150 I,L 195 V VAL195:A -0.248 6 -0.441,-0.118 7,5 150/150 L,I,V 196 P PRO196:A -0.996 9 -1.077,-0.960 9,9 150/150 S,T,P 197 R ARG197:A -0.953 9 -1.013,-0.931 9,9 150/150 K,N,G,S,A,R 198 K LYS198:A -1.081 9 -1.108,-1.077 9,9 150/150 N,K 199 G GLY199:A -0.605 7 -0.711,-0.562 8,7 150/150 V,G,S,C,A,T,M 200 V VAL200:A -0.727 8 -0.832,-0.665 8,8 150/150 A,V,I 201 I ILE201:A 0.802 2 0.434, 0.958 3,1 150/150 Q,A,H,L,M,R,I,F,E,N,S,G,T,D,V 202 E GLU202:A -1.052 9 -1.094,-1.036 9,9 150/150 E,N,Q 203 L LEU203:A -0.700 8 -0.794,-0.615 8,8 150/150 L,M,V,I,F 204 M MET204:A 0.699 2 0.434, 0.958 3,1 150/150 V,D,T,F,L,Q,A,M,K,S,G,I,N,H,R,Y 205 R ARG205:A -0.781 8 -0.867,-0.711 9,8 150/150 G,R,N,K 206 M MET206:A -0.762 8 -0.867,-0.711 9,8 150/150 M,L,S,H,Q,N,I 207 L LEU207:A -0.657 8 -0.794,-0.615 8,8 150/150 F,I,V,M,A,L 208 D ASP208:A 0.935 1 0.434, 0.958 3,1 149/150 T,G,S,K,D,V,R,L,A,Q,E,N,P 209 G GLY209:A 0.404 3 0.112, 0.655 5,2 150/150 V,D,G,S,T,I,P,N,E,Q,H,A,Y,M 210 G GLY210:A 1.208 1 0.655, 1.425 2,1 148/150 T,S,G,K,D,V,R,Q,L,A,E,N,I,P 211 D ASP211:A 0.339 4 0.112, 0.434 5,3 150/150 A,Q,P,N,E,S,G,T,D,K 212 N ASN212:A 2.539 1 1.425, 2.689 1,1 150/150 P,I,E,N,H,Q,A,R,M,D,V,K,G,S,T 213 P PRO213:A 2.689 1 1.425, 2.689 1,1 150/150 M,R,Q,A,L,E,N,P,I,T,S,G,K,V,D 214 L LEU214:A -0.206 6 -0.372,-0.118 7,5 150/150 V,I,C,A,L,M 215 R ARG215:A 1.467 1 0.958, 1.425 1,1 150/150 T,S,C,G,K,D,V,R,L,A,Q,H,E,N 216 V VAL216:A 0.197 4 -0.011, 0.257 5,4 150/150 M,A,L,F,V,I 217 Q GLN217:A 0.544 3 0.257, 0.655 4,2 150/150 T,S,G,K,D,V,M,R,L,Q,A,F,N,E 218 I ILE218:A 0.199 4 -0.011, 0.257 5,4 150/150 V,I,W,F,A,L,M 219 G GLY219:A -0.465 7 -0.615,-0.372 8,7 150/150 H,A,L,Y,R,N,G,S,T 220 S SER220:A 0.821 2 0.434, 0.958 3,1 150/150 R,H,Q,A,N,E,P,T,G,S,K,D 221 N ASN221:A -0.358 6 -0.504,-0.297 7,6 150/150 R,Q,L,A,H,N,E,T,G,S,K,D 222 N ASN222:A -0.680 8 -0.794,-0.615 8,8 150/150 K,S,T,F,N,L,A,Q,H,R,Y 223 I ILE223:A -0.238 6 -0.372,-0.118 7,5 150/150 M,L,A,F,I,V 224 R ARG224:A -0.299 6 -0.441,-0.212 7,6 150/150 N,E,Y,R,H,A,Q,K,V,T,C,S 225 A ALA225:A -0.391 7 -0.562,-0.297 7,6 150/150 M,S,L,A,F,I,V 226 H HIS226:A 1.331 1 0.958, 1.425 1,1 150/150 G,C,S,K,H,Y,R,I,N,T,V,D,Q,L,A,F,E 227 V VAL227:A 0.293 4 -0.011, 0.434 5,3 150/150 W,K,V,D,T,G,C,S,N,F,I,R,M,A,L 228 G GLY228:A 0.832 2 0.434, 0.958 3,1 150/150 K,D,V,T,G,S,N,E,P,L,Q,A 229 D ASP229:A 1.301 1 0.655, 1.425 2,1 150/150 I,P,E,N,Q,A,H,M,R,V,D,K,S,G,T 230 F PHE230:A 0.057 5 -0.118, 0.112 5,5 150/150 S,T,V,L,A,M,Y,I,F,N 231 I ILE231:A 0.247 4 -0.011, 0.434 5,3 150/150 A,L,Q,M,R,Y,I,E,S,C,G,T,V,D,K 232 F PHE232:A -0.754 8 -0.867,-0.711 9,8 150/150 I,V,F,L,M 233 T THR233:A -0.734 8 -0.832,-0.665 8,8 150/150 I,L,H,Q,R,M,V,S,T 234 S SER234:A -0.846 8 -0.931,-0.794 9,8 150/150 V,T,C,A,S 235 K LYS235:A -1.024 9 -1.077,-1.013 9,9 150/150 K,R,Q 236 L LEU236:A -0.872 9 -0.960,-0.832 9,8 150/150 I,V,L 237 V VAL237:A -0.828 8 -0.900,-0.794 9,8 150/150 I,V,L 238 D ASP238:A -0.751 8 -0.867,-0.711 9,8 150/150 D,E,N,S,T 239 G GLY239:A -0.855 9 -0.960,-0.794 9,8 150/150 E,A,S,G 240 R ARG240:A -0.590 7 -0.711,-0.504 8,7 150/150 R,Q,A,E,T,S,K,V 241 F PHE241:A -0.845 8 -0.931,-0.794 9,8 150/150 F,Y 242 P PRO242:A -1.079 9 -1.113,-1.058 9,9 150/150 P 243 D ASP243:A -0.716 8 -0.832,-0.665 8,8 150/150 D,P,E,K,N,S,A 244 Y TYR244:A -0.943 9 -1.013,-0.900 9,9 150/150 Y,F 245 R ARG245:A 0.332 4 0.112, 0.434 5,3 150/150 G,S,T,D,K,A,H,Q,R,M,E,N 246 R ARG246:A -0.865 9 -0.960,-0.832 9,8 149/150 K,S,A,G,R,Y 247 V VAL247:A -0.976 9 -1.036,-0.960 9,9 149/150 A,L,V,I 248 L LEU248:A -0.847 8 -0.931,-0.794 9,8 149/150 L,M,T,I,V,F 249 P PRO249:A -0.726 8 -0.867,-0.665 9,8 149/150 T,L,H,F,E,P 250 K LYS250:A 0.821 2 0.434, 0.958 3,1 149/150 T,S,G,K,V,R,Q,H,A,L,N,E,P,I 251 N ASN251:A 1.218 1 0.655, 1.425 2,1 149/150 K,D,T,G,S,E,N,I,R,Y,L,H,Q,A 252 P PRO252:A 0.027 5 -0.212, 0.112 6,5 149/150 F,N,P,I,Y,H,Q,L,A,K,D,T,C,S,G 253 D ASP253:A 0.250 4 -0.011, 0.434 5,3 149/150 G,S,T,D,K,H,L,Q,Y,R,P,N,E 254 K LYS254:A -0.294 6 -0.441,-0.212 7,6 149/150 A,L,Q,H,R,N,S,G,T,V,K 255 H HIS255:A 2.560 1 1.425, 2.689 1,1 149/150 K,S,C,G,N,I,R,H,V,T,E,F,P,M,Q,L,A 256 L LEU256:A 0.264 4 -0.011, 0.434 5,3 149/150 I,V,F,L,A,M,T 257 E GLU257:A 1.746 1 0.958, 2.689 1,1 149/150 T,D,V,A,L,Q,M,P,F,E,S,K,W,H,Y,R,I,N 258 A ALA258:A -0.076 5 -0.297,-0.011 6,5 149/150 T,G,C,S,V,M,L,A,F,I 259 G GLY259:A 0.606 3 0.257, 0.655 4,2 149/150 G,S,K,D,R,H,Q,A,N,E,P 260 C CYS260:A -0.269 6 -0.441,-0.212 7,6 149/150 T,C,S,W,K,V,R,M,Q,H,A,N,P 261 D ASP261:A 0.893 1 0.434, 0.958 3,1 149/150 K,V,D,T,G,S,N,E,I,R,M,A,H,L,Q 262 L LEU262:A 2.654 1 1.425, 2.689 1,1 149/150 Q,A,L,M,P,E,T,V,D,H,R,Y,I,N,G,S 263 L LEU263:A -0.691 8 -0.794,-0.615 8,8 149/150 M,L,F,I,V 264 K LYS264:A -0.327 6 -0.504,-0.212 7,6 149/150 S,T,K,L,A,Q,R,M,I,F 265 Q GLN265:A 0.223 4 -0.011, 0.257 5,4 149/150 E,N,L,H,Q,A,R,V,D,K,G,S,T 266 A ALA266:A -0.566 7 -0.665,-0.504 8,7 149/150 L,A,M,I,S,C,G,T,V 267 F PHE267:A -0.746 8 -0.832,-0.711 8,8 149/150 M,L,A,C,F,V 268 A ALA268:A -0.121 5 -0.297,-0.011 6,5 149/150 K,D,V,T,G,S,E,I,Y,R,M,L,Q,A 269 R ARG269:A -1.077 9 -1.108,-1.058 9,9 149/150 L,R 270 A ALA270:A -0.592 7 -0.711,-0.504 8,7 149/150 T,M,G,A,S,V,I 271 A ALA271:A -0.437 7 -0.562,-0.372 7,7 148/150 M,A,N,I,T,S,G,V 272 I ILE272:A -0.987 9 -1.036,-0.960 9,9 148/150 I,V,T,L,A 273 L LEU273:A -0.831 8 -0.931,-0.794 9,8 148/150 M,L,I,V 274 S SER274:A -0.870 9 -0.931,-0.832 9,8 148/150 A,S,C,T 275 N ASN275:A -0.773 8 -0.867,-0.711 9,8 147/150 E,N,Y,H,A,Q,D,T,S 276 E GLU276:A -0.694 8 -0.794,-0.615 8,8 148/150 K,E,D 277 K LYS277:A -0.743 8 -0.832,-0.711 8,8 148/150 N,K,S,L,H,R 278 F PHE278:A -0.473 7 -0.615,-0.372 8,7 148/150 Y,H,L,F,I,T,G,S,V 279 R ARG279:A -0.649 8 -0.754,-0.562 8,7 148/150 N,K,Q,A,C,H,R 280 G GLY280:A -0.761 8 -0.867,-0.711 9,8 148/150 P,N,G,A,S 281 V VAL281:A -0.757 8 -0.832,-0.711 8,8 148/150 A,V,I 282 R ARG282:A -0.536 7 -0.665,-0.441 8,7 148/150 L,H,Q,M,Y,R,I,F,E,N,C,T,K 283 L LEU283:A -0.102 5 -0.297,-0.011 6,5 148/150 M,L,C,W,F,I,V 284 Y TYR284:A 0.807 2 0.434, 0.958 3,1 148/150 T,V,D,M,Q,L,A,F,E,G,S,K,Y,R,H,N,I 285 V VAL285:A -0.027 5 -0.212, 0.112 6,5 148/150 N,F,I,V,M,L,A 286 S SER286:A 1.176 1 0.655, 1.425 2,1 148/150 K,V,D,T,G,S,N,E,R,H,A,Q 287 E GLU287:A 2.681 1 1.425, 2.689 1,1 148/150 H,L,A,Q,R,P,E,N,G,S,T,D,K 288 N ASN288:A 0.764 2 0.434, 0.958 3,1 148/150 N,E,H,L,Q,A,D,K,S,C,G,T 289 Q GLN289:A 1.447 1 0.958, 1.425 1,1 147/150 E,F,M,A,Q,L,V,T,N,I,R,H,K,C,S,G 290 L LEU290:A -0.466 7 -0.615,-0.372 8,7 148/150 M,L,C,F,V,I 291 K LYS291:A 0.590 3 0.257, 0.655 4,2 148/150 E,N,I,R,M,H,L,A,Q,K,V,T,G,S,C 292 I ILE292:A -0.675 8 -0.794,-0.615 8,8 148/150 I,V,M,L,A 293 T THR293:A 0.265 4 -0.011, 0.434 5,3 148/150 G,S,C,I,N,H,R,Y,V,T,E,F,L,A,Q,M 294 A ALA294:A -0.723 8 -0.832,-0.665 8,8 148/150 C,A,S,G,T,I,V 295 N ASN295:A -0.307 6 -0.441,-0.212 7,6 148/150 V,D,K,S,T,I,N,Q,A,H,R 296 N ASN296:A -1.056 9 -1.094,-1.036 9,9 148/150 S,A,N 297 P PRO297:A -0.285 6 -0.441,-0.212 7,6 148/150 P,I,N,Q,L,A,M,V,S,T 298 E GLU298:A -0.553 7 -0.665,-0.504 8,7 148/150 K,D,Y,Q,H,A,E,F 299 Q GLN299:A -0.655 8 -0.754,-0.615 8,8 148/150 E,F,N,A,Q,H,R,D,G,S,T 300 E GLU300:A -0.975 9 -1.036,-0.931 9,9 148/150 D,E,G 301 E GLU301:A -0.353 6 -0.504,-0.297 7,6 148/150 I,N,E,Q,A,M,V,K,S,T 302 A ALA302:A -1.000 9 -1.058,-0.987 9,9 148/150 V,G,A,S 303 E GLU303:A 0.188 4 -0.011, 0.257 5,4 148/150 C,S,K,R,H,N,I,T,D,V,M,L,A,Q,E,F 304 E GLU304:A -0.830 8 -0.931,-0.794 9,8 148/150 A,D,V,E 305 I ILE305:A 0.045 5 -0.212, 0.112 6,5 148/150 D,V,T,E,F,L,Q,A,M,K,G,C,S,I,N,R,Y 306 L LEU306:A 0.029 5 -0.212, 0.112 6,5 148/150 L,M,V,I,F 307 D ASP307:A 0.421 3 0.112, 0.655 5,2 148/150 T,G,S,K,V,D,M,Q,A,E,F,P 308 V VAL308:A -0.424 7 -0.562,-0.372 7,7 148/150 T,L,S,A,G,I,V 309 T THR309:A 1.216 1 0.655, 1.425 2,1 148/150 T,S,G,K,D,Y,Q,H,A,N,E,I,P 310 Y TYR310:A -0.805 8 -0.900,-0.754 9,8 148/150 F,W,V,Y,T 311 S SER311:A 1.466 1 0.958, 1.425 1,1 148/150 P,F,E,A,L,Q,D,V,T,I,N,H,R,K,C,S,G 312 G GLY312:A -0.040 5 -0.297, 0.112 6,5 148/150 P,N,E,F,Q,H,A,R,Y,V,D,K,S,G,T 313 A ALA313:A 1.476 1 0.958, 1.425 1,1 148/150 S,G,T,D,K,Q,A,I,P,E,N 314 E GLU314:A 2.576 1 1.425, 2.689 1,1 148/150 K,D,V,T,G,S,E,F,N,P,R,A,Q 315 M MET315:A -0.128 6 -0.297,-0.011 6,5 148/150 L,M,I,V,F 316 E GLU316:A -0.543 7 -0.665,-0.441 8,7 148/150 Q,A,M,E,S,T,D,K 317 I ILE317:A -0.865 9 -0.931,-0.832 9,8 148/150 L,S,M,V,I 318 G GLY318:A -0.583 7 -0.711,-0.504 8,7 148/150 I,V,A,S,G 319 F PHE319:A -1.032 9 -1.077,-1.013 9,9 148/150 L,F,I 320 N ASN320:A -1.086 9 -1.108,-1.077 9,9 148/150 Q,N 321 V VAL321:A -0.717 8 -0.794,-0.665 8,8 148/150 N,V,I,S,L,A 322 S SER322:A -0.177 6 -0.372,-0.118 7,5 148/150 N,F,I,R,Y,A,Q,K,T,G,S 323 Y TYR323:A -1.069 9 -1.108,-1.058 9,9 148/150 Y,F 324 V VAL324:A -0.517 7 -0.665,-0.441 8,7 148/150 I,V,F,L,M 325 L LEU325:A -0.197 6 -0.372,-0.118 7,5 148/150 N,I,M,L,H,Q,K,V,T 326 D ASP326:A -0.863 9 -0.931,-0.832 9,8 148/150 N,E,D 327 V VAL327:A -0.869 9 -0.931,-0.832 9,8 148/150 I,V,A,L,G 328 L LEU328:A -0.520 7 -0.665,-0.441 8,7 148/150 A,L,M,I,F,C,S,T,V 329 N ASN329:A 0.124 4 -0.118, 0.257 5,4 148/150 T,S,G,K,D,R,H,Q,A,E,N 330 A ALA330:A -0.275 6 -0.441,-0.212 7,6 148/150 Q,H,A,I,N,E,F,G,S,T,V 331 L LEU331:A -0.048 5 -0.297, 0.112 6,5 148/150 V,T,S,F,I,M,L,A 332 K LYS332:A 1.084 1 0.655, 1.425 2,1 148/150 D,K,S,G,T,P,E,N,H,Q,A,R 333 C CYS333:A 0.609 3 0.257, 0.655 4,2 148/150 V,D,T,G,C,S,E,N,P,R,Q,H,A 334 E GLU334:A 0.790 2 0.434, 0.958 3,1 148/150 K,D,V,T,S,G,N,E,P,A,Q 335 N ASN335:A 1.189 1 0.655, 1.425 2,1 140/150 D,V,T,E,A,L,Q,M,K,G,C,S,I,N,H,R,Y 336 V VAL336:A -0.509 7 -0.615,-0.441 8,7 148/150 V,C,S,T,I,L,A,M 337 R ARG337:A 1.019 1 0.655, 1.425 2,1 148/150 I,F,E,N,Q,L,A,H,R,D,V,K,S,C,T 338 M MET338:A 0.688 2 0.257, 0.958 4,1 148/150 V,W,C,I,F,A,L,M 339 M MET339:A 0.344 4 0.112, 0.434 5,3 148/150 T,V,D,L,A,Q,M,F,E,S,C,G,W,K,H,Y,R,I,N 340 L LEU340:A -0.219 6 -0.372,-0.118 7,5 148/150 L,M,I,V,K,F 341 T THR341:A -0.110 5 -0.297,-0.011 6,5 148/150 E,N,I,P,M,R,A,Q,L,K,V,D,T,S,G 342 D ASP342:A -0.525 7 -0.665,-0.441 8,7 148/150 E,N,Q,K,D,T,S,G 343 S SER343:A 0.079 5 -0.118, 0.257 5,4 148/150 V,S,G,T,P,E,F,N,A 344 V VAL344:A -0.186 6 -0.372,-0.118 7,5 148/150 N,E,L,H,Q,A,M,D,V,K,S,G,T 345 S SER345:A -0.635 8 -0.754,-0.562 8,7 148/150 K,D,T,G,S,E,N,R,M,A,H,Q 346 S SER346:A -1.011 9 -1.058,-0.987 9,9 148/150 P,A,C,S,G 347 V VAL347:A -0.394 7 -0.562,-0.297 7,6 148/150 T,C,S,G,V,M,L,A,I 348 Q GLN348:A -0.711 8 -0.832,-0.665 8,8 148/150 F,I,R,M,H,L,Q,V 349 I ILE349:A -0.231 6 -0.372,-0.118 7,5 148/150 M,L,W,F,I,V 350 E GLU350:A -0.153 6 -0.372,-0.011 7,5 148/150 E,L,Q,A,H,Y,R,D,V,K,W,S,C,T 351 D ASP351:A 0.767 2 0.434, 0.958 3,1 147/150 V,D,T,P,E,F,Q,L,A,M,K,S,G,I,N,Y 352 A ALA352:A 2.166 1 0.958, 2.689 1,1 148/150 K,G,S,C,I,N,H,Y,R,V,D,T,P,E,L,Q,A 353 A ALA353:A 1.419 1 0.958, 1.425 1,1 148/150 E,N,P,Q,H,L,A,K,V,D,T,G,C,S 354 S SER354:A 1.083 1 0.655, 1.425 2,1 148/150 K,G,C,S,I,N,H,R,Y,V,D,T,P,E,F,A,L,Q 355 Q GLN355:A 2.674 1 1.425, 2.689 1,1 148/150 N,I,R,Y,H,K,S,C,G,E,F,P,M,Q,A,V,D,T 356 S SER356:A 2.119 1 0.958, 2.689 1,1 148/150 T,V,D,L,A,Q,E,F,P,S,G,K,Y,R,H,N 357 A ALA357:A -0.273 6 -0.441,-0.212 7,6 148/150 V,T,C,S,E,F,N,I,Y,H,A,Q 358 A ALA358:A 0.326 4 0.112, 0.434 5,3 148/150 T,S,K,D,V,M,R,H,L,Q,A,E,F,N,I 359 Y TYR359:A -0.820 8 -0.900,-0.754 9,8 148/150 Y,H,F 360 V VAL360:A -0.976 9 -1.036,-0.960 9,9 148/150 L,I,V 361 V VAL361:A -0.780 8 -0.867,-0.711 9,8 148/150 L,I,V 362 M MET362:A -1.092 9 -1.113,-1.077 9,9 148/150 S,M 363 P PRO363:A -1.039 9 -1.094,-1.013 9,9 148/150 P,L 364 M MET364:A -0.961 9 -1.013,-0.931 9,9 148/150 V,I,L,M 365 R ARG365:A -1.054 9 -1.094,-1.036 9,9 143/150 R,K 366 L LEU366:A -0.911 9 -0.987,-0.867 9,9 136/150 L,M,V,I *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.