Amino Acid Conservation Scores ======================================= - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 A ALA23:A -0.461 6* -1.263,-0.123 9,5 1/150 A 2 L LEU24:A -0.774 7* -1.341,-0.523 9,7 4/150 L 3 H HIS25:A -1.002 8* -1.378,-0.811 9,7 5/150 H 4 W TRP26:A 0.955 2* -0.123, 1.698 5,1 7/150 V,S,T,L,W 5 R ARG27:A 0.119 5 -0.437, 0.540 6,3 12/150 A,Q,W,R,K 6 A ALA28:A -0.278 6 -0.746, 0.008 7,5 13/150 A,G,E,V,K,T 7 A ALA29:A 0.592 3* -0.123, 1.153 5,1 17/150 V,S,I,A,L,F 8 G GLY30:A -0.302 6 -0.746, 0.008 7,5 22/150 F,A,G,V 9 A ALA31:A 1.119 2* 0.156, 1.698 5,1 28/150 S,W,L,T,I,A,G,Y 10 A ALA32:A -0.253 6 -0.603, 0.008 7,5 41/150 L,T,F,G,V,I,A 11 T THR33:A 0.434 4 0.008, 0.801 5,3 53/150 S,L,T,G,V,I,A,M,F 12 V VAL34:A 1.339 1 0.801, 1.698 3,1 58/150 F,M,I,A,V,G,T,L,S 13 L LEU35:A 0.679 3 0.156, 0.801 5,3 67/150 F,M,I,A,V,G,T,L,S 14 L LEU36:A 0.142 5 -0.238, 0.329 6,4 86/150 V,G,A,I,F,M,S,T,L 15 V VAL37:A 1.115 2 0.540, 1.153 3,1 103/150 Y,F,M,I,A,V,C,G,T,L,S 16 I ILE38:A 0.771 3 0.329, 1.153 4,1 116/150 T,L,N,S,F,M,P,A,I,V,G 17 V VAL39:A 0.578 3 0.156, 0.801 5,3 124/150 S,T,L,V,C,G,I,A,F,M 18 L LEU40:A 0.515 3 0.156, 0.801 5,3 126/150 A,I,V,C,G,Y,M,Q,S,W,T,L 19 L LEU41:A 0.746 3 0.329, 0.801 4,3 127/150 V,E,G,A,I,Q,F,Y,M,S,T,L,W 20 A ALA42:A 1.027 2 0.540, 1.153 3,1 128/150 S,T,L,W,V,G,C,I,A,F,M 21 G GLY43:A 0.333 4 0.008, 0.540 5,3 131/150 S,L,T,I,A,G,C,V,M,F,Q 22 S SER44:A -0.739 7 -0.872,-0.677 8,7 133/150 G,C,S,A,L,T 23 Y TYR45:A -0.026 5 -0.342, 0.156 6,5 134/150 S,N,L,T,W,C,V,A,I,F,Y 24 L LEU46:A 0.221 4 -0.123, 0.329 5,4 135/150 A,I,G,V,M,F,S,L,T 25 A ALA47:A -0.204 6 -0.437,-0.123 6,5 136/150 A,I,E,V,G,F,M,S,T,L 26 V VAL48:A -0.110 5 -0.342, 0.008 6,5 136/150 Q,M,F,Y,V,I,L,R,W,H,S 27 L LEU49:A 1.864 1 1.153, 1.698 1,1 138/150 W,L,S,I,D,E,V,R,T,N,H,M,F,Y,Q,A,P 28 A ALA50:A 0.478 4 0.156, 0.540 5,3 139/150 L,T,S,M,F,Q,A,I,C,V 29 E GLU51:A -1.419 9 -1.482,-1.378 9,9 140/150 D,E,L 30 R ARG52:A 0.157 5 -0.123, 0.329 5,4 126/150 Y,Q,A,P,G,V,E,R,K,S,N,H 31 G GLY53:A 2.584 1 1.153, 3.134 1,1 120/150 S,N,H,R,K,T,A,P,D,G,E,V,Y,Q 32 A ALA54:A 0.265 4 0.008, 0.540 5,3 123/150 T,H,N,Q,F,M,P,A,L,K,S,V,E,G,D,I 33 P PRO55:A 0.590 3 0.156, 0.801 5,3 129/150 Q,P,A,E,V,D,G,K,R,T,N,S,H 34 G GLY56:A 1.460 1 0.801, 1.698 3,1 134/150 I,A,P,D,G,E,V,Q,S,N,H,K,R,L 35 A ALA57:A 0.801 3 0.329, 1.153 4,1 147/150 R,K,L,T,S,N,H,Q,A,P,G,D,E 36 Q GLN58:A 1.050 2 0.540, 1.153 3,1 147/150 A,P,G,D,V,E,F,Q,S,N,H,R,K,L,T 37 L LEU59:A -0.869 8 -0.984,-0.811 8,7 150/150 Y,F,M,Q,I,V,G,K,L,N,S,H 38 I ILE60:A 1.337 1 0.801, 1.698 3,1 150/150 Q,Y,M,P,A,T,R,H,N,E,V,D,G,I,L,K,S 39 T THR61:A -0.568 7 -0.746,-0.523 7,7 150/150 N,S,E,D,G,Y,T 40 Y TYR62:A -0.669 7 -0.811,-0.603 7,7 150/150 M,F,Y,I,A,P,G,V,W,L,S 41 P PRO63:A 0.340 4 0.008, 0.540 5,3 150/150 E,G,D,P,I,A,F,M,S,L,K,W 42 R ARG64:A 1.162 1 0.540, 1.153 3,1 150/150 R,K,L,T,S,N,H,Q,A,I,D,G,V,E 43 A ALA65:A -0.791 7 -0.930,-0.746 8,7 150/150 A,S,C,G,Q,T 44 L LEU66:A 0.102 5 -0.123, 0.329 5,4 150/150 F,Y,M,A,I,V,C,G,W,L,S 45 W TRP67:A -1.324 9 -1.414,-1.263 9,9 150/150 W,Y 46 W TRP68:A -1.011 8 -1.178,-0.930 9,8 150/150 C,L,T,Y,F,W 47 S SER69:A -0.341 6 -0.523,-0.238 7,6 150/150 C,G,V,A,I,L,T,S 48 V VAL70:A 0.577 3 0.156, 0.801 5,3 150/150 V,C,G,I,A,Q,Y,F,M,S,T,L 49 E GLU71:A -0.330 6 -0.523,-0.238 7,6 150/150 V,E,I,A,Q,M,S,T 50 T THR72:A -1.315 9 -1.378,-1.263 9,9 150/150 V,S,A,I,T 51 A ALA73:A -0.540 7 -0.746,-0.437 7,6 150/150 L,T,S,M,F,A,I,V 52 T THR74:A -1.119 8 -1.221,-1.086 9,8 150/150 S,A,C,M,F,L,T 53 T THR75:A -1.467 9 -1.498,-1.449 9,9 150/150 S,T 54 V VAL76:A -1.279 9 -1.378,-1.263 9,9 150/150 M,L,T,I,V 55 G GLY77:A -1.456 9 -1.498,-1.449 9,9 150/150 G 56 Y TYR78:A -1.321 9 -1.414,-1.263 9,9 148/150 F,Y 57 G GLY79:A -1.421 9 -1.482,-1.378 9,9 150/150 S,G 58 D ASP80:A -1.471 9 -1.498,-1.449 9,9 150/150 D 59 L LEU81:A 0.543 3 0.156, 0.801 5,3 150/150 E,V,I,A,Q,Y,F,M,H,T,L,R,K 60 Y TYR82:A 0.522 3 0.156, 0.801 5,3 150/150 R,K,T,S,H,Y,F,I,A,C,V 61 P PRO83:A -1.448 9 -1.498,-1.449 9,9 150/150 P 62 V VAL84:A 0.106 5 -0.123, 0.329 5,4 150/150 H,N,L,T,R,K,V,E,A,I,P,Q 63 T THR85:A -1.271 9 -1.341,-1.221 9,9 150/150 G,S,T 64 L LEU86:A 3.123 1 1.698, 3.134 1,1 150/150 S,L,W,V,E,G,D,I,H,N,T,R,P,A,Y,F 65 W TRP87:A 2.936 1 1.698, 3.134 1,1 150/150 G,V,E,A,I,P,Q,M,F,Y,S,L,T,W 66 G GLY88:A -1.420 9 -1.482,-1.378 9,9 150/150 G,S 67 R ARG89:A -0.848 8 -0.984,-0.746 8,7 150/150 H,Q,K,R 68 C CYS90:A 1.585 1 0.801, 1.698 3,1 150/150 L,T,G,C,V,A,I,M,F 69 V VAL91:A 0.166 4 -0.123, 0.329 5,4 150/150 M,Y,F,A,I,V,W,L,T,N 70 A ALA92:A -0.904 8 -1.036,-0.811 8,7 150/150 D,C,G,V,A,S,T 71 V VAL93:A 0.476 4 0.156, 0.540 5,3 150/150 F,M,V,C,G,A,I,T,L,S 72 V VAL94:A 1.469 1 0.801, 1.698 3,1 150/150 C,G,V,I,A,M,F,S,L,T,W 73 V VAL95:A -0.320 6 -0.523,-0.238 7,6 150/150 S,L,T,W,C,V,I,A,M,F 74 M MET96:A -0.891 8 -1.036,-0.811 8,7 150/150 T,L,S,Y,F,M,A,I,V,C 75 V VAL97:A 0.987 2 0.540, 1.153 3,1 150/150 M,F,Y,G,V,A,I,P,L,T,S 76 A ALA98:A 1.384 1 0.801, 1.698 3,1 150/150 S,T,L,A,I,V,G,C,F,Y,M 77 G GLY99:A -1.178 9 -1.303,-1.133 9,8 150/150 E,G,A,S,L 78 I ILE100:A -0.882 8 -1.036,-0.811 8,7 150/150 I,V,F,Y,M,W,T,L 79 T THR101:A -0.040 5 -0.342, 0.156 6,5 150/150 L,T,S,D,G,V,I,A 80 S SER102:A -0.128 5 -0.342, 0.008 6,5 150/150 T,L,S,F,M,V,I,A 81 F PHE103:A -0.298 6 -0.523,-0.123 7,5 150/150 V,C,I,A,Y,F,N,T,L 82 G GLY104:A -0.959 8 -1.086,-0.872 8,8 148/150 G,V,S,A,Q,T 83 L LEU105:A -0.214 6 -0.437,-0.123 6,5 148/150 S,T,L,V,G,A,I,F,Y,M 84 V VAL106:A -0.468 6 -0.677,-0.342 7,6 140/150 V,P,A,I,F,Y,H,L,W 85 T THR107:A -0.871 8 -0.984,-0.811 8,7 135/150 S,T,A,I,V,G,F,M 86 A ALA108:A -0.726 7 -0.872,-0.603 8,7 129/150 N,P,S,A,G,T 87 A ALA109:A -0.288 6 -0.523,-0.123 7,5 123/150 T,L,K,N,S,Q,F,Y,M,V,G,A,I 88 L LEU110:A -0.254 6 -0.523,-0.123 7,5 115/150 V,I,T,L,F,M 89 A ALA111:A -0.751 7 -0.930,-0.677 8,7 110/150 A,I,S,V,G,T 90 T THR112:A -0.746 7 -0.930,-0.677 8,7 101/150 V,E,G,D,A,N,S,T 91 W TRP113:A 0.706 3 0.156, 0.801 5,3 97/150 L,T,R,W,H,S,N,Y,F,G,E,V,I,A 92 F PHE114:A -0.811 7 -0.984,-0.677 8,7 92/150 L,Y,W,F,M,V,I 93 V VAL115:A -0.121 5 -0.437, 0.008 6,5 79/150 R,T,L,I,A,V,F,M 94 G GLY116:A 0.988 2 0.329, 1.153 4,1 54/150 H,N,S,R,E,D,G,A,Q 95 R ARG117:A 0.265 4 -0.238, 0.540 6,3 38/150 Q,A,P,G,E,K,R,S,N,H 96 E GLU118:A 0.453 4 -0.123, 0.801 5,3 16/150 I,H,D,E,R,Q 97 Q GLN119:A -0.467 6 -0.984,-0.123 8,5 6/150 G,E,Q *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.