ConSurf: the projection of evolutionary conservation scores of residues on protein structures Landau M., Mayrose I., Rosenberg Y., Glaser F., Martz E., Pupko T., and Ben-Tal N. Nucl. Acids Res. 33:W299-W302. (2005) PDF. Bioinformatics 19: 163-164. (2003) PDF.
Method of calculating the amino acid conservation scores (obligatory) Method: Bayesian Max. Likelihood (ML) Protein Structure (obligatory) Enter the PDB ID: Or Enter your own PDB file Chain Identifier Looking for a PDB ID? Try our pre-calculated ConSurf DataBase User-Provided Multiple Sequence Alignment (optional) Enter your own MSA file Query sequence name in MSA file User-Provided TREE file (optional) Enter your own TREE file (in Newick format) Please enter your e-mail address: We will use this address in case your job has exceeded its maximal running time. Send a link to the results by e-mail Providing your e-mail address ensures that you don't lose the URL to your results. Advanced Options Running Parameters (Irrelevant when uploading users MSA) Build Multiple Sequence Alignment using MUSCLECLUSTALW Collect the Homologues from SWISS-PROTUniProt Max. Number of Homologues No. of PSI-BLAST Iterations 1 2 3 4 5 PSI-BLAST E-value Cutoff Model of substitution for proteins JTT (default) mtREV (for mitochondrial proteins) cpREV (for chloroplasts proteins) WAG Dayhoff